Effect of glutamine supplementation on cardiometabolic risk factors and inflammatory markers: a systematic review and meta-analysis.
Adult
Aged
Biomarkers
/ blood
Blood Glucose
/ drug effects
C-Reactive Protein
/ metabolism
Cardiometabolic Risk Factors
Dietary Supplements
/ adverse effects
Female
Glucose Metabolism Disorders
/ blood
Glutamine
/ adverse effects
Humans
Inflammation
/ blood
Inflammation Mediators
/ blood
Male
Middle Aged
Randomized Controlled Trials as Topic
Risk Assessment
Treatment Outcome
Young Adult
Cardiometabolic risk factors
Glutamine
Meta-analysis
Systematic review
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
17 04 2021
17 04 2021
Historique:
received:
05
11
2020
accepted:
06
04
2021
entrez:
18
4
2021
pubmed:
19
4
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers. The processes of systematic reviews and meta-analyses were performed according to the PRISMA checklist. PubMed, Web of Sciences, Cochrane library, and Scopus databases were search for relevant studies without time or language restrictions up to December 30, 2020. All randomized clinical trials which assessed the effect of glutamine supplementation on "glycemic indices", "level of triglyceride, "and "inflammatory markers" were included in the study. The effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers was assessed using a standardized mean difference (SMD) and 95% confidence interval (CI). Heterogeneity between among studies was assessed using Cochran Q-statistic and I-square. Random/fixed-effects meta-analysis method was used to estimate the pooled SMD. The risk of bias for the included trials was evaluated using the Cochrane quality assessment tool. In total, 12 studies that assessed the effect of glutamine supplementation on cardio-metabolic risk factors were included in the study. Meta-analysis showed that glutamine supplementation significantly decreased significantly serum levels of FPG [SMD: - 0.73, 95% CI - 1.35, - 0.11, I Our findings showed that glutamine supplementation might have a positive effect on FPG and CRP; both of which are crucial as cardio-metabolic risk factors. However, supplementation had no significant effect on other cardio-metabolic risk factors.
Sections du résumé
BACKGROUND
Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers.
METHODS
The processes of systematic reviews and meta-analyses were performed according to the PRISMA checklist. PubMed, Web of Sciences, Cochrane library, and Scopus databases were search for relevant studies without time or language restrictions up to December 30, 2020. All randomized clinical trials which assessed the effect of glutamine supplementation on "glycemic indices", "level of triglyceride, "and "inflammatory markers" were included in the study. The effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers was assessed using a standardized mean difference (SMD) and 95% confidence interval (CI). Heterogeneity between among studies was assessed using Cochran Q-statistic and I-square. Random/fixed-effects meta-analysis method was used to estimate the pooled SMD. The risk of bias for the included trials was evaluated using the Cochrane quality assessment tool.
RESULTS
In total, 12 studies that assessed the effect of glutamine supplementation on cardio-metabolic risk factors were included in the study. Meta-analysis showed that glutamine supplementation significantly decreased significantly serum levels of FPG [SMD: - 0.73, 95% CI - 1.35, - 0.11, I
CONCLUSION
Our findings showed that glutamine supplementation might have a positive effect on FPG and CRP; both of which are crucial as cardio-metabolic risk factors. However, supplementation had no significant effect on other cardio-metabolic risk factors.
Identifiants
pubmed: 33865313
doi: 10.1186/s12872-021-01986-8
pii: 10.1186/s12872-021-01986-8
pmc: PMC8053267
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Inflammation Mediators
0
Glutamine
0RH81L854J
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
190Références
Diabetologia. 2003 Nov;46(11):1512-21
pubmed: 12955201
J Biol Chem. 2004 Apr 2;279(14):13393-401
pubmed: 14736887
Biomed Res Int. 2015;2015:545467
pubmed: 26495301
Minerva Anestesiol. 2011 May;77(5):488-95
pubmed: 21540803
Heart Lung Circ. 2013 May;22(5):360-5
pubmed: 23253886
JPEN J Parenter Enteral Nutr. 2000 Jul-Aug;24(4):215-22
pubmed: 10885715
Nutrition. 2012 Apr;28(4):397-402
pubmed: 22055478
BMJ. 2011 Oct 18;343:d5928
pubmed: 22008217
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120
Clin Nutr. 2002 Oct;21(5):409-16
pubmed: 12381339
Nutrients. 2019 Mar 01;11(3):
pubmed: 30832230
Intensive Care Med. 2005 Aug;31(8):1079-86
pubmed: 15973519
J Appl Physiol (1985). 2001 Jun;90(6):2403-10
pubmed: 11356807
Nutrients. 2019 May 11;11(5):
pubmed: 31083508
JPEN J Parenter Enteral Nutr. 2012 Jan;36(1):43-52
pubmed: 22235107
Eur J Anaesthesiol. 2014 Apr;31(4):212-8
pubmed: 24374803
PLoS One. 2013 Aug 30;8(8):e72817
pubmed: 24023648
Mol Cell Endocrinol. 2019 Jul 1;491:110433
pubmed: 31018148
Crit Care. 2014 Apr 18;18(2):R76
pubmed: 24745648
Nutrition. 2001 Jan;17(1):35-40
pubmed: 11165886
Am J Clin Nutr. 2009 Jan;89(1):106-113
pubmed: 19056578
Crit Care. 2013 Mar 06;17(2):305
pubmed: 23470218
Lancet. 1998 Sep 5;352(9130):772-6
pubmed: 9737282
Nutrients. 2019 Apr 17;11(4):
pubmed: 30999561
Nutrition. 2013 Jun;29(6):813-20
pubmed: 23415393
BMC Med Res Methodol. 2005 Apr 20;5:13
pubmed: 15840177
J Nutr. 2011 Jul;141(7):1233-8
pubmed: 21593352
J Nutr. 1996 Jan;126(1):273-9
pubmed: 8558312
Br J Nutr. 2005 Jul;94(1):19-26
pubmed: 16115328
Phytother Res. 2020 Dec;34(12):3113-3123
pubmed: 32614129
Nutrients. 2018 Oct 23;10(11):
pubmed: 30360490
Nutrition. 2015 Jan;31(1):119-26
pubmed: 25466655
Acta Cir Bras. 2011;26 Suppl 1:77-81
pubmed: 21971663
Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G317-23
pubmed: 11804853
Ann Surg. 1992 Feb;215(2):114-9
pubmed: 1546897
Front Med (Lausanne). 2019 Mar 27;6:54
pubmed: 30972338
Nutr Metab (Lond). 2020 Sep 25;17:80
pubmed: 32983244
Crit Care Med. 2011 Jun;39(6):1263-8
pubmed: 21336131
Physiol Res. 2015;64(4):505-12
pubmed: 25470514
Ann Intensive Care. 2011 Jul 18;1(1):25
pubmed: 21906372
J Oral Biol Craniofac Res. 2015 Jan-Apr;5(1):34-9
pubmed: 25853046
Clin Nutr. 2013 Jun;32(3):386-90
pubmed: 23021433
Clin Nutr. 2009 Feb;28(1):15-20
pubmed: 18835506
Lancet. 1993 May 29;341(8857):1363-5
pubmed: 8098788
Burns Trauma. 2017 Apr 17;5:11
pubmed: 28428966
Crit Care Med. 2006 Feb;34(2):381-6
pubmed: 16424718
J Cell Physiol. 2005 Aug;204(2):392-401
pubmed: 15795900
Nutrition. 2017 Feb;34:1-6
pubmed: 28063503
Stat Med. 1991 Nov;10(11):1665-77
pubmed: 1792461
Eur J Clin Nutr. 2014 Nov;68(11):1264-6
pubmed: 25226827
JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S62-6
pubmed: 10483898