Associations of Visceral Adipose Tissue and Skeletal Muscle Density With Incident Stroke, Myocardial Infarction, and All-Cause Mortality in Community-Dwelling 70-Year-Old Individuals: A Prospective Cohort Study.
Absorptiometry, Photon
Aged
Aging
/ physiology
Body Fat Distribution
Cause of Death
/ trends
Female
Humans
Incidence
Independent Living
Intra-Abdominal Fat
/ diagnostic imaging
Male
Muscle, Skeletal
/ diagnostic imaging
Myocardial Infarction
/ epidemiology
Prospective Studies
Risk Assessment
/ methods
Risk Factors
Stroke
/ epidemiology
Survival Rate
/ trends
Sweden
/ epidemiology
body composition
cardiovascular disease
ectopic fat
obesity
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
04 05 2021
04 05 2021
Historique:
pubmed:
20
4
2021
medline:
26
10
2021
entrez:
19
4
2021
Statut:
ppublish
Résumé
Background Aging leads to increased visceral adipose tissue (VAT) and reduced skeletal muscle density. To which extent these are associated with the risk of stroke, myocardial infarction (MI), and all-cause mortality in older adults is unknown. Methods and Results A total of 3294 70-year-old individuals (49.6% women) underwent a health examination in Umeå, Sweden, during 2012 to 2018. VAT and muscle density were measured using dual-energy x-ray absorptiometry and peripheral quantitative computed tomography. Cases of stroke, MI, and all-cause mortality were collected through national registers. Cox regressions were used to calculate hazard ratios (HRs) and 95% CIs per SD greater VAT and per SD lower muscle density. During a mean follow-up of 3.6 years, there were 108 cases of stroke or MI, and 97 deaths. Greater VAT (adjusted HR [aHR], 1.56; 95% CI, 1.09-2.22), but not lower muscle density (aHR, 1.14; 95% CI, 0.97-1.34), was associated with increased risk of stroke or MI. Neither VAT (aHR, 0.95; 95% CI, 0.65-1.41) nor muscle density (aHR, 1.11; 95% CI, 0.92-1.34) was associated with all-cause mortality. The association of VAT with stroke or MI was only significant in men (aHR, 1.86; 95% CI, 1.19-2.91) but not women (aHR, 0.60; 95% CI, 0.25-1.42) (
Identifiants
pubmed: 33870709
doi: 10.1161/JAHA.120.020065
pmc: PMC8200751
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e020065Commentaires et corrections
Type : CommentIn
Références
Hypertension. 2017 May;69(5):957-963
pubmed: 28264917
Circulation. 2012 Sep 4;126(10):1301-13
pubmed: 22949540
PLoS Med. 2020 Jun 11;17(6):e1003135
pubmed: 32525878
Am J Med. 2018 Jun;131(6):684-692.e12
pubmed: 29518370
Scand J Public Health. 2021 Jun;49(4):377-383
pubmed: 32349623
Lancet. 2011 Aug 27;378(9793):815-25
pubmed: 21872750
Circulation. 2020 Mar 3;141(9):e139-e596
pubmed: 31992061
Scand J Public Health. 2018 Jul;46(5):522-529
pubmed: 29569525
Sports Med. 2021 Feb;51(2):339-349
pubmed: 33063268
Circulation. 2015 Oct 27;132(17):1639-47
pubmed: 26294660
Int J Epidemiol. 2001 Oct;30 Suppl 1:S30-4
pubmed: 11759848
Am J Epidemiol. 2004 Oct 15;160(8):741-9
pubmed: 15466496
J Am Coll Cardiol. 2013 Sep 3;62(10):921-5
pubmed: 23850922
Eur J Radiol. 2016 Aug;85(8):1505-11
pubmed: 27005009
Ageing Res Rev. 2009 Oct;8(4):339-48
pubmed: 19576300
PLoS Med. 2020 Jun 8;17(6):e1003138
pubmed: 32511229
Am J Epidemiol. 2016 Jan 1;183(1):53-60
pubmed: 26643983
Obes Rev. 2021 Jan;22(1):e13088
pubmed: 32692447
Obesity (Silver Spring). 2012 May;20(5):1109-14
pubmed: 22240726
Obesity (Silver Spring). 2018 Mar;26(3):505-512
pubmed: 29286209
Metabolism. 2020 Oct;111:154321
pubmed: 32712219
J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1133-40
pubmed: 25838547
Med Sci Sports Exerc. 2018 Mar;50(3):458-467
pubmed: 28991040
Obes Rev. 2020 Aug;21(8):e13035
pubmed: 32319198
Prog Cardiovasc Dis. 2018 Jul - Aug;61(2):182-189
pubmed: 29990534
J Gerontol A Biol Sci Med Sci. 2017 Apr 01;72(4):513-519
pubmed: 27567109
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Age Ageing. 2016 Jul;45(4):529-34
pubmed: 27076522
Neuroepidemiology. 2013;40(4):240-6
pubmed: 23364278
Curr Opin Clin Nutr Metab Care. 2010 May;13(3):260-4
pubmed: 20179586
Lancet. 2016 Aug 20;388(10046):761-75
pubmed: 27431356
J Bone Miner Res. 2019 Jul;34(7):1264-1274
pubmed: 30866105
Eur J Clin Nutr. 2020 Aug;74(8):1181-1191
pubmed: 32123345
Obes Rev. 2010 Jan;11(1):11-8
pubmed: 19656312
J Am Heart Assoc. 2018 Aug 21;7(16):e009172
pubmed: 30369326
PLoS One. 2013;8(2):e56415
pubmed: 23409182
Eur J Epidemiol. 2017 Sep;32(9):765-773
pubmed: 28983736
J Am Heart Assoc. 2021 May 4;10(9):e020065
pubmed: 33870709
Endocr Rev. 2000 Dec;21(6):697-738
pubmed: 11133069
J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):87-92
pubmed: 23525474
Lancet. 2005 Nov 5;366(9497):1640-9
pubmed: 16271645
Metabolism. 2020 Jun;107:154230
pubmed: 32298722
Am J Clin Nutr. 2017 Jul;106(1):130-135
pubmed: 28566307
Diabetes Care. 1999 Nov;22(11):1808-12
pubmed: 10546012
J Gerontol A Biol Sci Med Sci. 2009 Mar;64(3):377-84
pubmed: 19181709
Obesity (Silver Spring). 2015 Apr;23(4):893-7
pubmed: 25755182
Int J Epidemiol. 2012 Jun;41(3):805-17
pubmed: 22467292
J Gerontol A Biol Sci Med Sci. 2021 Jan 18;76(2):277-285
pubmed: 32504466
Bone. 2019 Mar;120:446-451
pubmed: 30537557
Obesity (Silver Spring). 2015 Jan;23(1):220-7
pubmed: 25294681
J Appl Physiol (1985). 2000 Jul;89(1):104-10
pubmed: 10904041
J Cardiopulm Rehabil Prev. 2020 Sep;40(5):302-309
pubmed: 32796492
BMC Public Health. 2011 Jun 09;11:450
pubmed: 21658213
NCHS Data Brief. 2012 Sep;(106):1-8
pubmed: 23102091
Cardiol Rev. 2014 Jul-Aug;22(4):163-70
pubmed: 24896249
J Am Geriatr Soc. 2019 Aug;67(8):1625-1631
pubmed: 31012497
J Clin Densitom. 2012 Jul-Sep;15(3):355-61
pubmed: 22521542
Obes Rev. 2016 Aug;17(8):664-90
pubmed: 27213481