Neonatal IL-4 exposure decreases adipogenesis of male rats into adulthood.
Adipocytes
/ drug effects
Adipogenesis
/ drug effects
Adipose Tissue, White
/ drug effects
Aging
/ drug effects
Animals
Animals, Newborn
Cell Differentiation
/ drug effects
Cell Proliferation
/ drug effects
Cells, Cultured
Female
Interleukin-4
/ pharmacology
Male
Pregnancy
Rats
Rats, Sprague-Dawley
Time Factors
IL-4
Ucp1
adipocyte precursor
adipogenesis
beige
differentiation
neonatatal
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
20
4
2021
medline:
31
7
2021
entrez:
19
4
2021
Statut:
ppublish
Résumé
The cytokine interleukin 4 (IL-4) can increase beige adipogenesis in adult rodents. However, neonatal animals use a distinct adipocyte precursor compartment for adipogenesis as compared with adults. In this study, we address whether IL-4 can induce persistent effects on adipose tissue when administered subcutaneously in the interscapular region during the neonatal period in Sprague-Dawley rats. We injected IL-4 into neonatal male rats during
Identifiants
pubmed: 33870712
doi: 10.1152/ajpendo.00600.2020
pmc: PMC8285599
doi:
Substances chimiques
Interleukin-4
207137-56-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1148-E1157Subventions
Organisme : HHS | National Institutes of Health (NIH)
ID : DK114054
Organisme : NIDDK NIH HHS
ID : R01 DK055704
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES019851
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : P30DK19525
Organisme : NIDDK NIH HHS
ID : P30 DK019525
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114054
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120982
Pays : United States
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