The Prenatal Morphomechanic Impact of Agenesis of the Corpus Callosum on Human Brain Structure and Asymmetry.
Adult
Agenesis of Corpus Callosum
/ diagnostic imaging
Brain
/ embryology
Cerebral Cortex
/ embryology
Corpus Callosum
/ embryology
Female
Fetus
/ diagnostic imaging
Functional Laterality
Gestational Age
Humans
Magnetic Resonance Imaging
Pregnancy
Prenatal Diagnosis
Retrospective Studies
Temporal Lobe
/ embryology
callosal agenesis
computational anatomy
cortical morphology
fetal brain
magnetic resonance imaging
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
received:
27
11
2020
revised:
23
02
2021
accepted:
23
02
2021
pubmed:
20
4
2021
medline:
11
3
2022
entrez:
19
4
2021
Statut:
ppublish
Résumé
Genetic, molecular, and physical forces together impact brain morphogenesis. The early impact of deficient midline crossing in agenesis of the Corpus Callosum (ACC) on prenatal human brain development and architecture is widely unknown. Here we analyze the changes of brain structure in 46 fetuses with ACC in vivo to identify their deviations from normal development. Cases of complete ACC show an increase in the thickness of the cerebral wall in the frontomedial regions and a reduction in the temporal, insular, medial occipital and lateral parietal regions, already present at midgestation. ACC is associated with a more symmetric configuration of the temporal lobes and increased frequency of atypical asymmetry patterns, indicating an early morphomechanic effect of callosal growth on human brain development affecting the thickness of the pallium along a ventro-dorsal gradient. Altered prenatal brain architecture in ACC emphasizes the importance of conformational forces introduced by emerging interhemispheric connectivity on the establishment of polygenically determined brain asymmetries.
Identifiants
pubmed: 33872347
pii: 6237946
doi: 10.1093/cercor/bhab066
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4024-4037Subventions
Organisme : Austrian Science Fund FWF
ID : I 3925
Pays : Austria
Organisme : Austrian Research Fund
ID : I3925-B27
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.