Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients.
COVID-19
/ metabolism
Calcium
/ metabolism
Calcium Channel Blockers
/ therapeutic use
Dantrolene
/ therapeutic use
Drug Repositioning
Endoplasmic Reticulum
/ metabolism
Humans
Mortality
Multiple Organ Failure
Ryanodine Receptor Calcium Release Channel
/ metabolism
SARS-CoV-2
Sarcoplasmic Reticulum
/ metabolism
Sepsis
/ drug therapy
Shock, Septic
/ drug therapy
COVID-19 Drug Treatment
Journal
European review for medical and pharmacological sciences
ISSN: 2284-0729
Titre abrégé: Eur Rev Med Pharmacol Sci
Pays: Italy
ID NLM: 9717360
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
entrez:
20
4
2021
pubmed:
21
4
2021
medline:
1
5
2021
Statut:
ppublish
Résumé
Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.
Identifiants
pubmed: 33877683
doi: 10.26355/eurrev_202104_25569
pmc: PMC8612127
mid: NIHMS1757096
pii:
doi:
Substances chimiques
Calcium Channel Blockers
0
Ryanodine Receptor Calcium Release Channel
0
Dantrolene
F64QU97QCR
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3136-3144Subventions
Organisme : NIA NIH HHS
ID : R01 AG061447
Pays : United States
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