Secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs: A case report.
Adult
Diagnosis, Differential
Female
High-Throughput Nucleotide Sequencing
/ methods
Humans
Immunohistochemistry
/ methods
Lung Neoplasms
/ secondary
Lymphatic Metastasis
/ pathology
Mammary Analogue Secretory Carcinoma
/ diagnosis
Neoplasm Recurrence, Local
Oncogene Proteins, Fusion
/ genetics
S100 Proteins
/ metabolism
Secretoglobins
/ metabolism
Skin Neoplasms
/ pathology
Sweat Glands
/ metabolism
Thoracic Surgery, Video-Assisted
/ methods
ETV6-NTRK3 gene fusion
adnexal and skin appendage neoplasms
axillary sweat glands
malignant behavior
secretory carcinoma
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
12
03
2021
received:
29
01
2021
accepted:
06
04
2021
pubmed:
22
4
2021
medline:
15
12
2021
entrez:
21
4
2021
Statut:
ppublish
Résumé
Secretory carcinoma of the skin is an extremely rare adnexal tumor, histopathologically identical to homologous lesions in the salivary glands and breast tissue. Although this tumor was previously reported as indolent, we report a case of secretory carcinoma of the skin with metastases and recurrence. The patient, a 31-year-old women, had a subcutaneous mass in the right axilla. The resected specimen contained a circumscribed mass, with proliferating tumor cells that exhibited prominent nucleoli. They exhibited glandular and papillary growth patterns and there were amphophilic secretions in the glands. Immunohistochemically, the tumor cells were positive for mammaglobin and S100. The tumor was surrounded by sweat glands and there was no mammary glandular tissue, suggesting that it was derived from axillary sweat glands. Accordingly, we made a diagnosis of secretory carcinoma of the skin. Four years after the operation, there were metastases in both lungs. The resected specimen revealed a tumor identical to that of the original skin tumor. Next-generation sequencing-based multiplex gene assay performed on the metastatic tissue revealed an ETV6-NTRK3 fusion gene. This is a rare case report of secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs.
Substances chimiques
ETV6-NTRK3 fusion protein, human
0
Oncogene Proteins, Fusion
0
S100 Proteins
0
Secretoglobins
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1069-1074Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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