Glucocorticoid exposure predicts survival in female baboons.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
11
11
2020
accepted:
02
03
2021
entrez:
22
4
2021
pubmed:
23
4
2021
medline:
19
4
2022
Statut:
epublish
Résumé
Are differences in hypothalamic-pituitary-adrenal (HPA) axis activation across the adult life span linked to differences in survival? This question has been the subject of considerable debate. We analyze the link between survival and fecal glucocorticoid (GC) measures in a wild primate population, leveraging an unusually extensive longitudinal dataset of 14,173 GC measurements from 242 adult female baboons over 1634 female years. We document a powerful link between GCs and survival: Females with relatively high current GCs or high lifelong cumulative GCs face an elevated risk of death. A hypothetical female who maintained GCs in the top 90% for her age across adulthood would be expected to lose 5.4 years of life relative to a female who maintained GCs in the bottom 10% for her age. Hence, differences among individuals in HPA axis activity provide valuable prognostic information about disparities in life span.
Identifiants
pubmed: 33883141
pii: 7/17/eabf6759
doi: 10.1126/sciadv.abf6759
pmc: PMC8059933
pii:
doi:
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : P2C HD065563
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053308
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD088558
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031719
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053330
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Références
Integr Comp Biol. 2016 Aug;56(2):185-97
pubmed: 27252190
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4770-5
pubmed: 11287659
Anim Behav. 2014 Aug;94:87-99
pubmed: 26997663
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1219-1228
pubmed: 30538209
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14158-63
pubmed: 16983099
Annu Rev Psychol. 2015 Jan 3;66:733-67
pubmed: 25148851
Glob Chang Biol. 2017 Nov;23(11):4907-4921
pubmed: 28589633
Lancet. 2007 Sep 22;370(9592):1089-100
pubmed: 17822755
Am J Primatol. 2004 Sep;64(1):95-106
pubmed: 15356861
Endocr Rev. 2000 Feb;21(1):55-89
pubmed: 10696570
Gen Comp Endocrinol. 2013 Sep 1;190:188-93
pubmed: 23770216
Ann N Y Acad Sci. 2011 Aug;1231:17-22
pubmed: 21651565
J Epidemiol Community Health. 2006 Jul;60(7):633-9
pubmed: 16790837
Exp Gerontol. 1999 Sep;34(6):721-32
pubmed: 10579633
Mol Ecol. 2012 Feb;21(3):715-31
pubmed: 21988698
Science. 2020 May 22;368(6493):
pubmed: 32439765
Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20052-20062
pubmed: 32747546
Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8424-8430
pubmed: 32229565
Horm Behav. 2003 Jan;43(1):2-15
pubmed: 12614627
Soc Sci Med. 2013 Jan;77:164-72
pubmed: 23228966
Horm Behav. 2013 Jul;64(2):240-9
pubmed: 23998668
Nat Clin Pract Endocrinol Metab. 2008 Sep;4(9):496-505
pubmed: 18695699
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14882-7
pubmed: 26504236
Gen Comp Endocrinol. 2002 Aug;128(1):57-64
pubmed: 12270788
Am J Primatol. 2001 Apr;53(4):139-54
pubmed: 11283975
J Clin Endocrinol Metab. 2014 May;99(5):1569-82
pubmed: 24517153
Aging Cell. 2018 Aug;17(4):e12778
pubmed: 29806171
Horm Behav. 2009 Mar;55(3):375-89
pubmed: 19470371
Horm Behav. 2008 Aug;54(3):410-6
pubmed: 18514196
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6490-5
pubmed: 22493251
Horm Behav. 2009 Jun;56(1):1-10
pubmed: 19281813
Arch Gen Psychiatry. 1997 Dec;54(12):1137-43
pubmed: 9400351
Am J Phys Anthropol. 2011 Feb;144(2):169-76
pubmed: 20721938
Nat Commun. 2016 Apr 19;7:11181
pubmed: 27091302
Ann N Y Acad Sci. 2005 Jun;1046:54-74
pubmed: 16055843
Gen Comp Endocrinol. 2003 Jun 15;132(2):264-71
pubmed: 12812774
Biometrics. 1997 Mar;53(1):330-9
pubmed: 9147598
Gen Comp Endocrinol. 2008 Jul;157(3):288-95
pubmed: 18602555
Evol Anthropol. 2013 Sep-Oct;22(5):213-25
pubmed: 24166922
Integr Comp Biol. 2019 Aug 1;59(2):251-263
pubmed: 31168615
J Behav Med. 2006 Aug;29(4):377-87
pubmed: 16758315
Arch Intern Med. 1997 Oct 27;157(19):2259-68
pubmed: 9343003
Mol Ecol. 2008 Apr;17(8):1998-2011
pubmed: 18363664
Stress. 2019 Sep;22(5):548-562
pubmed: 31124379
Gen Comp Endocrinol. 2018 May 1;260:9-17
pubmed: 29427633
Proc Biol Sci. 2014 Oct 22;281(1793):
pubmed: 25209936
Science. 2011 Jul 15;333(6040):357-60
pubmed: 21764751
Biometrics. 2011 Sep;67(3):819-29
pubmed: 21306352
Gen Comp Endocrinol. 2000 Dec;120(3):260-75
pubmed: 11121291
Horm Behav. 2017 May;91:68-83
pubmed: 28284709
Philos Trans R Soc Lond B Biol Sci. 2020 Nov 9;375(1811):20190621
pubmed: 32951552
Stat Med. 2015 Jun 30;34(14):2181-95
pubmed: 24634327
Behaviour. 1974;49(3):227-67
pubmed: 4597405
J Comp Physiol B. 2012 Oct;182(7):861-79
pubmed: 22415475
Science. 2005 Apr 29;308(5722):648-52
pubmed: 15860617
Stat Methods Med Res. 2019 Dec;28(12):3502-3515
pubmed: 30378472
Trends Ecol Evol. 2009 Nov;24(11):634-42
pubmed: 19679371
Mol Cell Endocrinol. 2020 Jan 15;500:110640
pubmed: 31715223