Characteristics of very high-energy electron beams for the irradiation of deep-seated targets.
FLASH
VHEE
high energy electrons
treatment planning
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
07
03
2021
received:
12
12
2020
accepted:
06
04
2021
pubmed:
23
4
2021
medline:
30
7
2021
entrez:
22
4
2021
Statut:
ppublish
Résumé
Driven by advances in accelerator technology and the potential of exploiting the FLASH effect for the treatment of deep-seated targets (>5 cm), there is an active interest in the construction of devices to deliver very high-energy electron (VHEE) beams for radiation therapy. The application of novel VHEE devices, however, requires an assessment of the tradeoffs between the different beam parameter choices including beam energies, beam divergences, and maximal field sizes. This study systematically examines the dosimetric beam properties of VHEE beams, determining their clinical usefulness while marking their limits of applications for different beam configurations. We performed Monte Carlo simulations of the dose distributions of electron beams for different energies (25-250 MeV), source-to-surface distances (SSD) (50 cm, 100 cm, parallel), and field sizes (2 cm Very high-energy electrons beams with SSD 100 cm and parallel beams (infinite SSD) exhibit a linear to near-linear increase of TR as a function of energy in the simulated energy range and reach values well beyond the typical depths of lesions encountered in clinics (<20 cm). Their TR show a marked field size dependence only for field sizes <10 cm The findings presented in this study assess the performance of VHEE beams and offer a first estimate of treatment indications and tradeoffs for a given design of a VHEE device. SSD >100 cm results in clinically more favorable PDD. Beam energies of 100 MeV and above are needed to cover common tumors (5-15 cm in-depth) conformally. Higher energies provide an additional benefit specifically for small and deep-seated lesions due to their reduced lateral penumbrae.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3958-3967Informations de copyright
© 2021 American Association of Physicists in Medicine.
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