Combined epigenetic/genetic study identified an ALS age of onset modifier.

Age of Onset Aged Amyotrophic Lateral Sclerosis / diagnosis C9orf72 Protein / genetics Cohort Studies Epigenesis, Genetic / genetics Epigenomics / methods Female Genetic Association Studies / methods Heterozygote Humans Male Middle Aged Polymorphism, Single Nucleotide / genetics
ALS Age of onset CpG-SNPs DNA methylation Genetic association Modifier

Journal

Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673

Informations de publication

Date de publication:
23 04 2021
Historique:
received: 10 03 2021
accepted: 14 04 2021
entrez: 24 4 2021
pubmed: 25 4 2021
medline: 15 12 2021
Statut: epublish

Résumé

Age at onset of amyotrophic lateral sclerosis (ALS) is highly variable (eg, 27-74 years in carriers of the G

Identifiants

DOI: 10.1186/s40478-021-01183-w PMID: 33892821 PMC: PMC8066440
pubmed: 33892821
doi: 10.1186/s40478-021-01183-w
pii: 10.1186/s40478-021-01183-w
pmc: PMC8066440
doi:

Substances chimiques

C9orf72 Protein 0
C9orf72 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

75

Subventions

Organisme : Intramural Research Program of the NIH, National Institute on Aging
ID : Z01-AG000949-02

Références

Brain. 2018 Oct 1;141(10):2895-2907
pubmed: 30252044
Acta Neuropathol. 2013 Dec;126(6):859-79
pubmed: 24096617
Neural Plast. 2015;2015:573784
pubmed: 26301107
Brain. 2019 Nov 1;142(11):3375-3381
pubmed: 31580390
Methods Mol Biol. 2012;863:359-76
pubmed: 22359306
Mol Psychiatry. 2016 Aug;21(8):1112-24
pubmed: 26481318
Neurosci Insights. 2020 Jul 21;15:2633105520942221
pubmed: 32743556
Neuron. 2018 Mar 21;97(6):1268-1283.e6
pubmed: 29566793
Am J Hum Genet. 2016 May 5;98(5):956-962
pubmed: 27087318
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
EMBO Rep. 2018 Nov;19(11):
pubmed: 30206190
Mol Neurobiol. 2014 Apr;49(2):1017-30
pubmed: 24234234
Acta Neuropathol. 2020 May;139(5):943-946
pubmed: 32146547
Nat Rev Neurol. 2014 Nov;10(11):661-70
pubmed: 25311585
Neuron. 2011 Oct 20;72(2):257-68
pubmed: 21944779
Epigenetics Chromatin. 2016 Dec 7;9:56
pubmed: 27980682
Front Aging Neurosci. 2019 Aug 30;11:233
pubmed: 31543810
Bioinformatics. 2014 May 15;30(10):1363-9
pubmed: 24478339
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Annu Rev Neurosci. 2019 Jul 8;42:337-364
pubmed: 30939101
Am J Hum Genet. 2013 Jun 6;92(6):981-9
pubmed: 23731538
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
N Engl J Med. 2017 Jul 13;377(2):162-172
pubmed: 28700839
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
J Clin Invest. 1998 Jun 1;101(11):2351-63
pubmed: 9616206
Am J Epidemiol. 2007 Oct 1;166(7):810-6
pubmed: 17641152
Nature. 2016 Aug 17;536(7616):285-91
pubmed: 27535533
Exp Neurol. 2014 Dec;262 Pt B:75-83
pubmed: 24246281
Brain. 2012 Mar;135(Pt 3):751-64
pubmed: 22366792
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Acta Neuropathol. 2017 Aug;134(2):271-279
pubmed: 28439722
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Acta Neuropathol. 2015 Jan;129(1):39-52
pubmed: 25388784
Nat Neurosci. 2016 Jan;19(1):48-54
pubmed: 26619357
Arch Neurol. 2011 Feb;68(2):207-13
pubmed: 21320987
J Neurol Neurosurg Psychiatry. 2016 Nov;87(11):1268-1270
pubmed: 27154192

Auteurs

Ming Zhang (M)

Shanghai First Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, 200090, China. mingzhang@tongji.edu.cn.
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada. mingzhang@tongji.edu.cn.
Clinical Center for Brain and Spinal Cord Research, Tongji University, Shanghai, 200092, China. mingzhang@tongji.edu.cn.
Institute for Advanced Study, Tongji University, Shanghai, China. mingzhang@tongji.edu.cn.

Zhengrui Xi (Z)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.

Sara Saez-Atienzar (S)

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

Ruth Chia (R)

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

Danielle Moreno (D)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.

Christine Sato (C)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.

Mahdi Montazer Haghighi (M)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.

Bryan J Traynor (BJ)

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

Lorne Zinman (L)

Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.

Ekaterina Rogaeva (E)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada. ekaterina.rogaeva@utoronto.ca.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada. ekaterina.rogaeva@utoronto.ca.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Âge de début › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Protéine C9orf72 › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Combined epigenetic/genetic study identified...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Combined epigenetic/genetic study identified...