Targeted Use of Placebo Effects Decreases Experimental Itch in Atopic Dermatitis Patients: A Randomized Controlled Trial.
Adolescent
Adult
Aged
Conditioning, Classical
Dermatitis, Atopic
/ complications
Dimethindene
/ administration & dosage
Double-Blind Method
Female
Histamine
Histamine H1 Antagonists, Non-Sedating
/ administration & dosage
Humans
Infusions, Intravenous
Male
Middle Aged
Placebo Effect
Pruritus
/ chemically induced
Skin
/ pathology
Treatment Outcome
Young Adult
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
29
01
2021
accepted:
23
03
2021
pubmed:
25
4
2021
medline:
28
8
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
Evidence from pain research shows that the effectiveness of active pharmacological treatments can be enhanced by placebo effects. The "open drug administration" is superior to "hidden drug administration." In a randomized controlled trial, we aimed to show that the targeted use of placebo effects increases the efficacy of an antihistamine (dimetindene) infusion in participants with atopic dermatitis. We openly infused dimetindene (drug) in full sight with information (intervention group 1: OPEN-DRUG+INST), openly infused drug with an additional classical conditioning learning experience (intervention group 2: OPEN-DRUG+INST+COND) or infused drug without any information or sight (i.e., hidden administration (control group 1: HIDDEN-DRUG)). Control group 2 received a placebo infusion (saline) declared as dimetindene and also experienced the conditioning experience (PLAC+INST+COND). Itch was experimentally induced with histamine via a skin prick test. Outcome was assessed at the subjective (primary end point: experimental itch intensity, numeric rating scale), and objective level (secondary end point: wheal size, mm
Substances chimiques
Histamine H1 Antagonists, Non-Sedating
0
Dimethindene
661FH77Z3P
Histamine
820484N8I3
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
486-497Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2021 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
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