Peculiarities of promiscuous L-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids.
L-threonine transaldolases (LTTAs)
Natural product biosynthesis
Stereoselective chemoenzymatic synthesis
β-Hydroxy-α-amino acids (βHAAs)
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
17
02
2021
accepted:
07
04
2021
revised:
31
03
2021
pubmed:
27
4
2021
medline:
15
5
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
The introduction of β-hydroxy-α-amino acids (βHAAs) into organic molecules has received considerable attention as these molecules have often found widespread applications in bioorganic chemistry, medicinal chemistry and biomaterial science. Despite innovation of asymmetric synthesis of βHAAs, stereoselective synthesis to control the two chiral centres at C
Identifiants
pubmed: 33900425
doi: 10.1007/s00253-021-11288-w
pii: 10.1007/s00253-021-11288-w
pmc: PMC8072733
doi:
Substances chimiques
Amino Acids
0
Threonine
2ZD004190S
Glycine Hydroxymethyltransferase
EC 2.1.2.1
Transaldolase
EC 2.2.1.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3507-3520Subventions
Organisme : Scottish Funding Council
ID : COVID 19 grant extension and Bridging Fung
Organisme : IBIOIC
ID : PhD studentship
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P00380X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R00479X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R50547X/1
Pays : United Kingdom
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