Hierarchical Assembly Pathways of Spermine-Induced Tubulin Conical-Spiral Architectures.

Microtubules Polymers Spermine Tubulin
conical-spiral conical-spiral tubules inverted tubules self-assembly spermine time-resolved small-angle X-ray scattering tubulin

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
25 05 2021
Historique:
pubmed: 27 4 2021
medline: 10 6 2021
entrez: 26 4 2021
Statut: ppublish

Résumé

Tubulin, an essential cytoskeletal protein, assembles into various morphologies by interacting with an array of cellular factors. One of these factors is the endogenous polyamine spermine, which may promote and stabilize tubulin assemblies. Nevertheless, the assembled structures and their formation pathways are poorly known. Here we show that spermine induced the

Identifiants

DOI: 10.1021/acsnano.1c01374 PMID: 33900736
pubmed: 33900736
doi: 10.1021/acsnano.1c01374
doi:

Substances chimiques

Polymers 0
Tubulin 0
Spermine 2FZ7Y3VOQX

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

8836-8847

Auteurs

Raviv Dharan (R)

Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Karem, Jerusalem 9112102, Israel.
ORCID: 0000-0001-9783-9205

Asaf Shemesh (A)

Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
The Harvey M. Krueger Family Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Abigail Millgram (A)

Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
The Harvey M. Krueger Family Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.

Ran Zalk (R)

The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Gabriel A Frank (GA)

The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
ORCID: 0000-0001-8379-5133

Yael Levi-Kalisman (Y)

The Harvey M. Krueger Family Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
ORCID: 0000-0002-2764-2738

Israel Ringel (I)

Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Karem, Jerusalem 9112102, Israel.

Uri Raviv (U)

Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
The Harvey M. Krueger Family Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel.
ORCID: 0000-0001-5992-9437

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › Hierarchical Assembly Pathways of...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Hierarchical Assembly Pathways of...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Spermine › Hierarchical Assembly Pathways of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Hierarchical Assembly Pathways of...