SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Biomarkers
/ blood
COVID-19
/ epidemiology
Child
Cytokines
/ blood
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Inflammation
/ etiology
Inflammation Mediators
/ blood
Lymphohistiocytosis, Hemophagocytic
/ genetics
Models, Biological
Mucocutaneous Lymph Node Syndrome
/ epidemiology
Pandemics
SARS-CoV-2
/ immunology
Systemic Inflammatory Response Syndrome
/ epidemiology
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
22
02
2021
revised:
24
03
2021
accepted:
07
04
2021
entrez:
27
4
2021
pubmed:
28
4
2021
medline:
7
5
2021
Statut:
ppublish
Résumé
Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
Identifiants
pubmed: 33904890
pii: 212029
doi: 10.1084/jem.20210446
pmc: PMC8080850
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHGRI NIH HHS
ID : UM1 HG006504
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148963
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144315
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150300
Pays : United States
Organisme : Medical Research Council
ID : MR/S032304/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI151029
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG008956
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI088364
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI135091
Pays : United States
Investigateurs
Elie Haddad
(E)
Kathie Beland
(K)
Aurora Pujol
(A)
Agatha Schlüter
(A)
Laura Planas-Serra
(L)
Sergio Aguilera-Albesa
(S)
Juan Valencia-Ramos
(J)
Agustí Rodríguez-Palmero
(A)
Marta Gut
(M)
Jacques G Rivière
(JG)
Roger Colobran
(R)
Pere Soler-Palacin
(P)
Carlos Rodriguez-Gallego
(C)
Rebeca Perez De Diego
(R)
Carlos Flores
(C)
Laia Alsina
(L)
Daniel Blazquez-Gamero
(D)
Iolanda Jordan
(I)
Sevgi Keles
(S)
Melike Emiroglu
(M)
Ozge Metin Akcan
(OM)
Gulsum Alkan
(G)
Selma Erol Aytekin
(SE)
Yahya Gul
(Y)
Şadiye Kübra Tüter Öz
(ŞK)
Sefika Elmas Bozdemir
(SE)
Gulsum Iclal Bayhan
(GI)
Saliha Kanik-Yüksek
(S)
Aslınur Özkaya Parlakay
(AÖ)
Belgin Gülhan
(B)
Aysun Yahşi
(A)
Ahmet Osman Kilic
(AO)
Adem Karbuz
(A)
Emine Hafize Erdeniz
(EH)
Esra Akyüz Özkan
(EA)
Zerrin Orbak
(Z)
Şehnaz Aydemir
(Ş)
Jale Bengi Celik
(JB)
Bahar Kandemir
(B)
Gökhan Aytekin
(G)
Hasan Kapakli
(H)
Volkan Yarar
(V)
Alper Yosunkaya
(A)
Hulya Vatansev
(H)
Caner Aytekin
(C)
Selda Hancerli Torun
(SH)
Serdar Nepesov
(S)
Taner Coskuner
(T)
Betül Sözeri
(B)
Yasemin Kendir Demirkol
(YK)
Ozgur Kasapcopur
(O)
Mehmet Yıldız
(M)
Esra Sevketoglu
(E)
Nevin Hatipoğlu
(N)
Tayfun Özçelik
(T)
Osman Yesilbas
(O)
Zeynep Gökçe Gayretli Aydin
(ZG)
Anna Sediva
(A)
Adam Klocperk
(A)
Marketa Bloomfield
(M)
Isabelle Meyts
(I)
Selket Delafontaine
(S)
Filomeen Haerynck
(F)
Levi Hoste
(L)
Mohammad Shahrooei
(M)
Laura Marque
(L)
João Farela Neves
(JF)
Giuseppe Novelli
(G)
Antonio Novelli
(A)
Alessandro Aiuti
(A)
Giorgio Casari
(G)
Amed Aziz Bousfiha
(AA)
Saleh Zaid Almuhsen
(SZ)
Ali Sobh
(A)
Alenka Gagro
(A)
Fanny Bajolle
(F)
Damien Bonnet
(D)
Pierre Lebon
(P)
Weite Lei
(W)
Danyel Lee
(D)
Yoann Seeleuthner
(Y)
Peng Zhang
(P)
Majistor Maglorius
(M)
Quentin Philippot
(Q)
Simon Pelham
(S)
Paul Bastard
(P)
Qian Zhang
(Q)
Emmanuelle Jouanguy
(E)
Anne Puel
(A)
Jethro Herberg
(J)
Taco W Kuijpers
(TW)
Evangelos Bellos
(E)
Myrsini Kaforou
(M)
Stephanie Menikou
(S)
Qiang Pan-Hammarström
(Q)
Lennart Hammarström
(L)
Hassan Abolhassani
(H)
Yenan Bryceson
(Y)
Antonio Condino-Neto
(A)
Carolina Prando
(C)
Silvia Yumi Bando
(SY)
Andre Cavalcanti
(A)
Jacques Fellay
(J)
Geraldine Blanchard-Rohner
(G)
Davood Mansouri
(D)
Shima Mahmoudi
(S)
Oksana Boyarchuk
(O)
Alla Volokha
(A)
Anastasiia Bondarenko
(A)
Yuriy Stepanovskiy
(Y)
Trine Mogensen
(T)
Diederik van de Beek
(D)
Evangelos Andreakos
(E)
Maria Papadaki
(M)
Ahmad Abou Tayoun
(A)
Rabih Halwani
(R)
Fahd Al-Mulla
(F)
José Luis Franco
(JL)
Yu-Lung Lau
(YL)
Mike Kwan
(M)
Kohsuke Imai
(K)
Satoshi Okada
(S)
Alexandre Bolze
(A)
Manish J Butte
(MJ)
Elena Hsieh
(E)
Beth A Drolet
(BA)
Lisa Arkin
(L)
Yuval Itan
(Y)
Tom Maniatis
(T)
Moshe Arditi
(M)
Megan Cooper
(M)
Erica Schmitt
(E)
Samya Chakravorty
(S)
Mark S Anderson
(MS)
Helen C Su
(HC)
Luigi D Notarangelo
(LD)
Informations de copyright
© 2021 Sancho-Shimizu et al.
Déclaration de conflit d'intérêts
Disclosures: The authors declare no competing interests exist.
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