Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis.
Breast cancer
Single-cell DNA sequencing
Single-cell RNA sequencing
Tumor microenvironment
Journal
Journal of experimental & clinical cancer research : CR
ISSN: 1756-9966
Titre abrégé: J Exp Clin Cancer Res
Pays: England
ID NLM: 8308647
Informations de publication
Date de publication:
27 Apr 2021
27 Apr 2021
Historique:
received:
01
12
2020
accepted:
15
04
2021
entrez:
28
4
2021
pubmed:
29
4
2021
medline:
25
11
2021
Statut:
epublish
Résumé
Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment (TME) and influence the progression of breast cancer and the therapeutic responses in patients. The exact composition of the intra-tumoral cells is mixed as the highly heterogeneous and dynamic nature of the TME. Recent advances in single-cell technologies such as single-cell DNA sequencing (scDNA-seq), single-cell RNA sequencing (scRNA-seq) and mass cytometry have provided new insights into the phenotypic and functional diversity of tumor-infiltrating cells in breast cancer. In this review, we have outlined the recent progress in single-cell characterization of breast tumor ecosystems, and summarized the phenotypic diversity of intra-tumoral cells and their potential prognostic relevance.
Identifiants
pubmed: 33906694
doi: 10.1186/s13046-021-01949-z
pii: 10.1186/s13046-021-01949-z
pmc: PMC8077685
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
142Subventions
Organisme : Project of China Key Research and Development Program Precision Medicine Research
ID : 2016YFC0905901
Organisme : National Key Research and Development Program of China
ID : ZDZX2017ZL-01
Organisme : High-level Innovation Team of Nanjing Medical University
ID : JX102GSP201727
Organisme : Wu Jieping Medical Foundation
ID : 320.6750.17006
Organisme : Key Medical Talents
ID : ZDRCA2016023
Organisme : National Natural Science Foundation of China
ID : 81972484
Organisme : The Collaborative Innovation Center for Tumor Individualization Focuses on Open Topics
ID : JX21817902/008
Organisme : Graduate Research and Innovation Projects of Jiangsu Province
ID : JX10213767
Références
Cancer Res. 2005 Dec 15;65(24):11743-51
pubmed: 16357187
Science. 2014 May 23;344(6186):921-5
pubmed: 24812208
Cancer Cell. 2017 May 8;31(5):711-723.e4
pubmed: 28486109
J Hepatol. 2016 May;64(5):1158-1166
pubmed: 26812075
Cell Stem Cell. 2010 Sep 3;7(3):271-2
pubmed: 20804960
Oncogene. 2017 Aug;36(31):4457-4468
pubmed: 28368410
Front Oncol. 2020 Apr 09;10:447
pubmed: 32328458
Nat Rev Cancer. 2016 Jul;16(7):447-62
pubmed: 27339708
Trends Immunol. 2017 Aug;38(8):542-557
pubmed: 28579323
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Nature. 2008 May 15;453(7193):410-4
pubmed: 18418378
Nat Commun. 2018 Dec 4;9(1):5150
pubmed: 30514914
Nat Rev Cancer. 2019 Jun;19(6):307-325
pubmed: 31092904
J Clin Oncol. 2010 Sep 10;28(26):4022-8
pubmed: 20644094
Cell Death Dis. 2015 Jun 18;6:e1792
pubmed: 26086965
PLoS Biol. 2015 Dec 30;13(12):e1002330
pubmed: 26717410
Ann Oncol. 2015 Aug;26(8):1533-46
pubmed: 25939896
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
Oncoimmunology. 2016 Jun 27;5(7):e1196312
pubmed: 27622051
Cancer Immunol Res. 2018 Dec;6(12):1472-1485
pubmed: 30266714
Nat Med. 2018 Jul;24(7):986-993
pubmed: 29942092
Cell Rep. 2017 Sep 19;20(12):2921-2934
pubmed: 28930685
Cell. 2010 Apr 2;141(1):39-51
pubmed: 20371344
Front Immunol. 2018 Nov 12;9:2582
pubmed: 30483257
Clin Cancer Res. 2008 Aug 15;14(16):5158-65
pubmed: 18698033
J Immunol. 2008 Oct 1;181(7):4666-75
pubmed: 18802069
Front Immunol. 2017 Sep 13;8:1124
pubmed: 28955340
Nat Commun. 2019 Aug 23;10(1):3817
pubmed: 31444334
Cell. 2019 Nov 14;179(5):1191-1206.e21
pubmed: 31730857
Nat Rev Clin Oncol. 2020 Jun;17(6):341-348
pubmed: 32112054
Nature. 2020 Jan;577(7791):549-555
pubmed: 31942075
J Immunol. 2008 Jul 1;181(1):346-53
pubmed: 18566400
Cell Res. 2017 Jan;27(1):109-118
pubmed: 27995907
F1000Prime Rep. 2014 Mar 03;6:13
pubmed: 24669294
Science. 2018 Nov 30;362(6418):1060-1063
pubmed: 30498128
Nature. 2020 Jan;577(7791):556-560
pubmed: 31942077
Cancer Res. 2016 Jul 15;76(14):4124-35
pubmed: 27216177
Cell. 2018 Aug 23;174(5):1293-1308.e36
pubmed: 29961579
Cancer Cell. 2016 Aug 8;30(2):324-336
pubmed: 27424807
Nat Med. 2013 Nov;19(11):1423-37
pubmed: 24202395
Cell Mol Immunol. 2017 Aug;14(8):662-674
pubmed: 28626234
Radiother Oncol. 2020 Jan;142:202-209
pubmed: 31767471
Nat Rev Drug Discov. 2018 Dec;17(12):887-904
pubmed: 30361552
Int J Cancer. 2012 Dec 1;131(11):2584-95
pubmed: 22487809
Nat Rev Clin Oncol. 2017 Jul;14(7):399-416
pubmed: 28117416
Cancer Cell. 2018 Apr 9;33(4):649-663.e4
pubmed: 29576375
Breast Cancer Res Treat. 2010 Aug;123(1):39-49
pubmed: 19898981
Cancers (Basel). 2019 Apr 03;11(4):
pubmed: 30987228
Br J Cancer. 2018 Jul;119(1):4-11
pubmed: 29808015
Nature. 2000 Aug 17;406(6797):747-52
pubmed: 10963602
Nat Rev Immunol. 2015 Mar;15(3):160-71
pubmed: 25698678
JCI Insight. 2018 Mar 22;3(6):
pubmed: 29563330
Science. 2010 Feb 5;327(5966):656-61
pubmed: 20133564
Nat Immunol. 2008 Nov;9(11):1225-35
pubmed: 18820683
Cancer Cell. 2018 Mar 12;33(3):463-479.e10
pubmed: 29455927
Cancer Res. 2018 Jan 1;78(1):157-167
pubmed: 29089297
Nat Immunol. 2016 Dec;17(12):1467-1478
pubmed: 27776108
Cell. 2017 May 4;169(4):736-749.e18
pubmed: 28475899
Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):444-457
pubmed: 28223433
Nat Rev Immunol. 2015 Jul;15(7):405-14
pubmed: 26027717
Expert Opin Drug Discov. 2015 Jan;10(1):91-9
pubmed: 25306865
Cell. 2020 Mar 19;180(6):1081-1097.e24
pubmed: 32142650
BMC Cancer. 2016 Nov 4;16(1):841
pubmed: 27809802
Nat Immunol. 2007 Nov;8(11):1217-26
pubmed: 17922015
Nature. 2017 Apr 13;544(7649):250-254
pubmed: 28371798
Immunology. 2013 Feb;138(2):105-15
pubmed: 23216602
Nat Commun. 2018 Mar 13;9(1):1056
pubmed: 29535360
J Immunol. 2006 Nov 15;177(10):7303-11
pubmed: 17082649
Cell. 2016 Mar 10;164(6):1198-1211
pubmed: 26967286
Nat Commun. 2018 Oct 16;9(1):4297
pubmed: 30327458
Immunity. 2017 Dec 19;47(6):1037-1050.e6
pubmed: 29221729
Cell. 2018 May 3;173(4):879-893.e13
pubmed: 29681456
Immunity. 2014 May 15;40(5):642-56
pubmed: 24837101
Cell. 2017 May 4;169(4):750-765.e17
pubmed: 28475900
Ann N Y Acad Sci. 2014 Jun;1319:47-65
pubmed: 24965257
Nat Med. 2009 Jan;15(1):68-74
pubmed: 19122658
Oncogene. 2015 Jul;34(28):3617-26
pubmed: 25263438
Nat Commun. 2017 May 05;8:15081
pubmed: 28474673
Nat Commun. 2016 Jun 08;7:11762
pubmed: 27272654
Cancer Med. 2019 Jun;8(6):3072-3085
pubmed: 31033233
Cancer Immunol Immunother. 2017 Aug;66(8):1015-1023
pubmed: 28382399
Endocr Rev. 2007 Aug;28(5):521-74
pubmed: 17640948
Cancer Res. 2006 Dec 1;66(23):11441-6
pubmed: 17145891
Cancer Res. 2017 May 15;77(10):2759-2769
pubmed: 28249895
J Neuroimmunol. 2018 Sep 15;322:63-73
pubmed: 30049538
Cell. 2019 Jul 11;178(2):346-360.e24
pubmed: 31257026
Cancer Cell. 2009 Sep 8;16(3):183-94
pubmed: 19732719
J Exp Med. 2018 Dec 3;215(12):3075-3093
pubmed: 30470719
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Oncotarget. 2016 Apr 26;7(17):24677-87
pubmed: 27013581
Breast Cancer Res. 2017 Jul 27;19(1):87
pubmed: 28750640
Cancer Treat Rev. 2016 May;46:9-19
pubmed: 27055087
Nat Commun. 2018 Sep 4;9(1):3588
pubmed: 30181541
Nat Cell Biol. 2014 Oct;16(10):942-50, 1-7
pubmed: 25173976
Cell. 2017 Dec 14;171(7):1611-1624.e24
pubmed: 29198524
J Biol Chem. 2009 Jul 10;284(28):19027-42
pubmed: 19389706
Nature. 2012 Jun 10;486(7403):353-60
pubmed: 22722193
Nature. 2010 Mar 11;464(7286):302-5
pubmed: 20220849
Cell. 2019 May 16;177(5):1330-1345.e18
pubmed: 30982598
CA Cancer J Clin. 2017 Mar;67(2):93-99
pubmed: 28094848
Clin Cancer Res. 2017 Apr 1;23(7):1710-1721
pubmed: 27702820
Clin Cancer Res. 2016 Dec 15;22(24):6290-6297
pubmed: 27267849
Curr Opin Biotechnol. 2019 Aug;58:129-136
pubmed: 30978643
EMBO J. 2020 Oct 1;39(19):e104063
pubmed: 32790115
Science. 2016 Apr 8;352(6282):189-96
pubmed: 27124452
CA Cancer J Clin. 2019 Jul;69(4):305-343
pubmed: 31116423
Immunity. 2016 Sep 20;45(3):669-684
pubmed: 27637149
Immunity. 2014 Jul 17;41(1):49-61
pubmed: 25035953
Cell Rep. 2015 Dec 29;13(12):2687-98
pubmed: 26711337
Cancer Discov. 2020 Sep;10(9):1330-1351
pubmed: 32434947
Bioinformatics. 2019 Nov 1;35(22):4679-4687
pubmed: 31028395
J Leukoc Biol. 2015 Dec;98(6):913-22
pubmed: 26337512
Genome Biol. 2016 Nov 17;17(1):231
pubmed: 27855702
Mol Oncol. 2016 Apr;10(4):517-25
pubmed: 26651914
Clin Cancer Res. 2015 Feb 15;21(4):687-92
pubmed: 25501578
Immunology. 2018 May;154(1):3-20
pubmed: 29313948
Clin Cancer Res. 2016 May 15;22(10):2417-26
pubmed: 26769751
Nat Rev Cancer. 2012 Apr 19;12(5):323-34
pubmed: 22513401
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1478-83
pubmed: 23766387
Cell. 2012 May 25;149(5):994-1007
pubmed: 22608083
Genome Biol. 2017 Dec 20;18(1):234
pubmed: 29262845
Cell Mol Immunol. 2020 Aug;17(8):843-855
pubmed: 31728048
Cell. 2015 May 21;161(5):1187-1201
pubmed: 26000487
Cancer Cell. 2018 Dec 10;34(6):939-953.e9
pubmed: 30472020
Nat Rev Cancer. 2016 Jul;16(7):431-46
pubmed: 27282249
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2639-44
pubmed: 12604779
Nat Rev Nephrol. 2018 Aug;14(8):479-492
pubmed: 29789704
Cell. 2019 Oct 31;179(4):846-863.e24
pubmed: 31668803
Nat Commun. 2020 Jan 21;11(1):404
pubmed: 31964880
J Clin Oncol. 2008 Mar 10;26(8):1275-81
pubmed: 18250347
Nat Commun. 2017 Apr 06;8:14979
pubmed: 28382931
Am J Pathol. 2008 Feb;172(2):486-94
pubmed: 18187565
Cell. 2018 Feb 22;172(5):1022-1037.e14
pubmed: 29429633
Nature. 2012 Apr 18;486(7403):346-52
pubmed: 22522925
Nat Rev Immunol. 2012 Mar 22;12(4):253-68
pubmed: 22437938