Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by
Actinobacteria
/ chemistry
Anti-Bacterial Agents
/ chemistry
Bacterial Proteins
/ chemistry
Base Sequence
Computer Simulation
Drug Evaluation, Preclinical
Gene Expression Regulation, Bacterial
Genomics
/ methods
Glucosamine
/ chemistry
Glycopeptides
/ chemistry
Multigene Family
Recombinant Proteins
/ chemistry
Tandem Mass Spectrometry
Teicoplanin
/ analogs & derivatives
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
21 05 2021
21 05 2021
Historique:
pubmed:
30
4
2021
medline:
25
8
2021
entrez:
29
4
2021
Statut:
ppublish
Résumé
Glycopeptide antibiotics (GPAs) are last defense line drugs against multidrug-resistant Gram-positive pathogens. Natural GPAs teicoplanin and vancomycin, as well as semisynthetic oritavancin, telavancin, and dalbavancin, are currently approved for clinical use. Although these antibiotics remain efficient, emergence of novel GPA-resistant pathogens is a question of time. Therefore, it is important to investigate the natural variety of GPAs coming from so-called "rare" actinobacteria. Herein we describe a novel GPA producer-
Identifiants
pubmed: 33913701
doi: 10.1021/acschembio.1c00170
pmc: PMC8291499
doi:
Substances chimiques
A 40926
0
Anti-Bacterial Agents
0
Bacterial Proteins
0
Glycopeptides
0
Recombinant Proteins
0
Teicoplanin
61036-62-2
dalbavancin
808UI9MS5K
Glucosamine
N08U5BOQ1K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
915-928Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/J/000PR9790
Pays : United Kingdom
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