Liver cell hydration and integrin signaling.
bile acids
cell swelling
functional selectivity
mechanotransduction
molecular dynamics simulations
tauroursodeoxycholate
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
26 08 2021
26 08 2021
Historique:
received:
12
03
2021
accepted:
12
04
2021
pubmed:
30
4
2021
medline:
31
12
2021
entrez:
29
4
2021
Statut:
epublish
Résumé
Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β
Identifiants
pubmed: 33915604
pii: hsz-2021-0193
doi: 10.1515/hsz-2021-0193
doi:
Substances chimiques
Bile Acids and Salts
0
Integrins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1033-1045Informations de copyright
© 2021 Michele Bonus et al., published by De Gruyter, Berlin/Boston.
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