Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach.
axonal cytoskeleton
axonal injury
mechanical behavior
neurofilaments
viscoelastic modeling
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
07 04 2021
07 04 2021
Historique:
received:
23
02
2021
revised:
29
03
2021
accepted:
05
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (MD) simulations on NFs to extract their strain rate-dependent behavior. It is found that they are highly stretchable and show multiple stages of unfolding. Furthermore, NFs show high tensile stiffness. Also, viscoelastic modeling shows that they correspond to simplified viscoelastic models. This study effectively enhances the existent axonal models focusing on axonal injury.
Identifiants
pubmed: 33917073
pii: biom11040540
doi: 10.3390/biom11040540
pmc: PMC8067762
pii:
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Office of Naval Research
ID : N00014-18-1-2082
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