Co-Therapy of Albendazole and Dexamethasone Reduces Pathological Changes in the Cerebral Parenchyma of Th-1 and Th-2 Dominant Mice Heavily Infected with
Albendazole
/ therapeutic use
Angiostrongylus cantonensis
/ pathogenicity
Animals
Brain
/ metabolism
Dexamethasone
/ therapeutic use
Disease Models, Animal
Drug Therapy, Combination
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
RNA
/ chemistry
Sequence Analysis, RNA
Strongylida Infections
/ drug therapy
Th1 Cells
/ cytology
Th2 Cells
/ cytology
Angiostrongylus cantonensis
RNA-seq
albendazole
dexamethasone
histopathology
pathological changes
scoring
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
06 04 2021
06 04 2021
Historique:
received:
09
02
2021
revised:
25
03
2021
accepted:
02
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Administration of albendazole alone was not very suitable for the treatment of cerebral angiostrongyliasis. This study was designed to evaluate the effects of the co-therapy of this drug and dexamethasone in Th-1 and Th-2 dominant mice infected with
Identifiants
pubmed: 33917604
pii: biom11040536
doi: 10.3390/biom11040536
pmc: PMC8067505
pii:
doi:
Substances chimiques
RNA
63231-63-0
Dexamethasone
7S5I7G3JQL
Albendazole
F4216019LN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 109-2320-B-182-032-MY3
Organisme : Chang Gung Memorial Hospital, Linkou
ID : CMRPD1H0343
Organisme : Chang Gung Memorial Hospital, Linkou
ID : CMRPD1H0443
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