Functions of Thrombospondin-1 in the Tumor Microenvironment.
CD36
CD47
angiogenesis
autophagy
cytotoxic T cells
integrins
natural killer cells
nitric oxide
transforming growth factor-β1
tumor-initiating cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2021
27 Apr 2021
Historique:
received:
01
03
2021
revised:
15
04
2021
accepted:
23
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
4
6
2021
Statut:
epublish
Résumé
The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. Decreased thrombospondin-1 mRNA and protein expression are associated with progression in several cancers, while expression by nonmalignant cells in the tumor microenvironment and circulating levels in cancer patients can be elevated.
Identifiants
pubmed: 33925464
pii: ijms22094570
doi: 10.3390/ijms22094570
pmc: PMC8123789
pii:
doi:
Substances chimiques
Integrins
0
Thrombospondin 1
0
thrombospondin-1, human
0
Thbs1 protein, mouse
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : T32 OD010957
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA218259
Pays : United States
Organisme : NIH HHS
ID : T32-OD010957
Pays : United States
Organisme : NIH HHS
ID : CA249349
Pays : United States
Organisme : American Cancer Society
ID : 133727-RSG-19-150-01-LIB
Organisme : NIH HHS
ID : ZIA SC009172
Pays : United States
Organisme : Fondation ARC pour la Recherche sur le Cancer
ID : COVID202001312
Organisme : NCI NIH HHS
ID : U01 CA218259
Pays : United States
Organisme : NIH HHS
ID : CA218259
Pays : United States
Références
J Vet Intern Med. 2012 Sep-Oct;26(5):1169-76
pubmed: 22816494
J Immunol. 2001 Feb 15;166(4):2427-36
pubmed: 11160302
J Immunol. 2005 Jan 15;174(2):654-61
pubmed: 15634883
Mol Cancer Ther. 2020 Mar;19(3):835-846
pubmed: 31879362
Surgery. 2008 Nov;144(5):752-61
pubmed: 19081017
Biomolecules. 2019 Nov 17;9(11):
pubmed: 31744193
Blood. 1996 Jan 1;87(1):180-9
pubmed: 8547640
Mol Cancer Ther. 2009 May;8(5):1148-56
pubmed: 19435875
Oncogenesis. 2016 May 30;5(5):e230
pubmed: 27239962
Trends Immunol. 2010 Jun;31(6):212-9
pubmed: 20452821
J Neurochem. 2009 Jan;108(2):430-6
pubmed: 19012741
JCI Insight. 2017 Jan 12;2(1):e89140
pubmed: 28097229
Cancer Res. 2000 Jan 15;60(2):457-66
pubmed: 10667601
Science. 2020 May 22;368(6493):897-901
pubmed: 32381591
Int J Cancer. 2015 Oct 15;137(8):1830-41
pubmed: 25857718
Oncotarget. 2015 Jul 20;6(20):17981-8000
pubmed: 26046793
J Cell Commun Signal. 2018 Mar;12(1):157-170
pubmed: 29188480
J Biol Chem. 1999 Apr 16;274(16):11408-16
pubmed: 10196234
Circ Res. 2007 Mar 16;100(5):712-20
pubmed: 17293482
Arch Biochem Biophys. 2011 May 15;509(2):147-56
pubmed: 21402050
Cell Mol Life Sci. 2008 Mar;65(5):700-12
pubmed: 18193162
Cancer Res. 2004 Feb 1;64(3):1026-36
pubmed: 14871834
Sci Rep. 2016 Jan 27;6:19684
pubmed: 26813769
J Cell Physiol. 2009 Jan;218(1):94-103
pubmed: 18726995
Sci Rep. 2020 Jan 24;10(1):1175
pubmed: 31980715
Matrix Biol. 2013 Aug 8;32(6):316-24
pubmed: 23499828
N Engl J Med. 2018 Nov 01;379(18):1711-1721
pubmed: 30380386
J Innate Immun. 2015;7(6):601-11
pubmed: 25998580
J Biol Chem. 2000 Jul 21;275(29):21797-800
pubmed: 10823814
Cancer Discov. 2013 May;3(5):578-89
pubmed: 23633432
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13224-9
pubmed: 21788504
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12485-90
pubmed: 11606713
Blood. 2006 Nov 15;108(10):3580-9
pubmed: 16882710
J Biol Chem. 2008 Feb 29;283(9):5699-707
pubmed: 18096704
Carcinogenesis. 2008 Jun;29(6):1115-23
pubmed: 18413367
J Exp Med. 2011 May 9;208(5):1083-92
pubmed: 21536744
Science. 2000 Jun 16;288(5473):2051-4
pubmed: 10856220
Matrix Biol. 2016 Sep;55:106-116
pubmed: 26992552
Curr Opin Immunol. 2014 Apr;27:60-74
pubmed: 24556090
J Cell Sci. 2006 Nov 1;119(Pt 21):4499-509
pubmed: 17046999
Clin Cancer Res. 2015 May 15;21(10):2325-37
pubmed: 25717063
Oncotarget. 2016 Mar 1;7(9):10133-52
pubmed: 26840086
Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):E2842; author reply E2844-5
pubmed: 22923696
J Natl Cancer Inst. 1986 May;76(5):781-91
pubmed: 3517452
Cancer Gene Ther. 2000 Dec;7(12):1537-42
pubmed: 11228532
J Biol Chem. 2006 Sep 8;281(36):26069-80
pubmed: 16835222
Oncogene. 2015 May 28;34(22):2949-50
pubmed: 26020734
Oncogene. 2002 Nov 14;21(52):7945-56
pubmed: 12439745
Am J Pathol. 2001 Nov;159(5):1949-56
pubmed: 11696456
Matrix Biol. 2018 Aug;68-69:28-43
pubmed: 29288716
Clin Cancer Res. 2000 Jul;6(7):2941-50
pubmed: 10914744
J Cancer. 2020 Feb 19;11(9):2667-2678
pubmed: 32201537
Immunology. 2014 Jun;142(2):176-92
pubmed: 24877199
Cancer Res. 2008 Sep 1;68(17):7090-9
pubmed: 18757424
Clin Cancer Res. 2017 Jan 15;23(2):523-535
pubmed: 27440269
Circ Res. 2007 May 11;100(9):1308-16
pubmed: 17413041
Cell Death Dis. 2019 Feb 27;10(3):199
pubmed: 30814491
Hepatology. 2014 Jul;60(1):179-91
pubmed: 24523067
Blood. 2012 Jun 7;119(23):5512-21
pubmed: 22427202
Leukemia. 2020 Mar;34(3):845-856
pubmed: 31712778
Cancer Res. 1993 Jan 15;53(2):378-87
pubmed: 8417830
PLoS One. 2015 Oct 13;10(10):e0139918
pubmed: 26461935
J Biol Chem. 2005 Aug 19;280(33):29637-44
pubmed: 15917238
EMBO J. 2004 Mar 24;23(6):1223-33
pubmed: 15014436
Nat Rev Clin Oncol. 2018 Oct;15(10):617-638
pubmed: 29795272
J Biol Chem. 2002 Nov 8;277(45):42859-66
pubmed: 12218055
Curr Opin Immunol. 2012 Apr;24(2):225-32
pubmed: 22310103
N Engl J Med. 1986 Dec 25;315(26):1650-9
pubmed: 3537791
Immunol Rev. 2017 Mar;276(1):145-164
pubmed: 28258703
BMC Cancer. 2015 Nov 02;15:833
pubmed: 26525741
J Cell Physiol. 2007 Mar;210(3):807-18
pubmed: 17154366
Neoplasia. 2018 Sep;20(9):930-942
pubmed: 30118999
J Cell Biol. 1992 Aug;118(3):693-701
pubmed: 1379247
Blood. 2008 Jan 15;111(2):613-23
pubmed: 17890448
J Clin Oncol. 2008 Dec 1;26(34):5583-8
pubmed: 18981463
Biochem Biophys Res Commun. 1990 Jul 31;170(2):867-72
pubmed: 1696478
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6656-61
pubmed: 22451919
Clin Cancer Res. 2018 Apr 15;24(8):1944-1953
pubmed: 29391350
Cancer Res. 2002 Feb 15;62(4):1191-5
pubmed: 11861403
Biochemistry. 2010 May 4;49(17):3685-94
pubmed: 20337411
J Immunol. 1993 Mar 1;150(5):1959-70
pubmed: 8436828
Cancer Gene Ther. 2020 May;27(5):356-367
pubmed: 31160686
Nat Chem Biol. 2016 Feb;12(2):109-16
pubmed: 26656090
Blood Adv. 2019 Apr 9;3(7):1145-1153
pubmed: 30962222
J Biol Chem. 2012 Feb 3;287(6):4211-21
pubmed: 22167178
J Biol Chem. 1999 Aug 20;274(34):24080-6
pubmed: 10446179
Circulation. 1999 Sep 28;100(13):1423-31
pubmed: 10500044
J Biol Chem. 2007 May 25;282(21):15404-15
pubmed: 17416590
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1985-90
pubmed: 22308318
Front Immunol. 2018 Dec 20;9:2985
pubmed: 30643501
Carcinogenesis. 2003 Feb;24(2):199-207
pubmed: 12584168
Biochem J. 1997 Sep 15;326 ( Pt 3):709-16
pubmed: 9334164
J Exp Med. 2003 Oct 20;198(8):1277-83
pubmed: 14568985
J Med Chem. 2005 Apr 21;48(8):2838-46
pubmed: 15828822
Matrix Biol. 2014 Jul;37:69-82
pubmed: 24582666
Matrix Biol. 2014 Jul;37:49-59
pubmed: 24887393
J Immunol. 1991 Jul 15;147(2):651-9
pubmed: 1712815
Cell. 2010 Sep 3;142(5):699-713
pubmed: 20813259
Am J Surg. 1968 Aug;116(2):192-7
pubmed: 5675275
Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):E2843; author reply E2844-5
pubmed: 22923695
J Immunol. 2014 Oct 15;193(8):3914-24
pubmed: 25200950
J Leukoc Biol. 2014 Nov;96(5):797-807
pubmed: 25001859
Int J Cancer. 1994 Oct 15;59(2):191-5
pubmed: 7927918
J Biol Chem. 2015 Apr 3;290(14):8975-86
pubmed: 25697354
Cancers (Basel). 2018 Jun 14;10(6):
pubmed: 29903994
Cancer Res. 2014 Dec 1;74(23):6771-83
pubmed: 25297630
Sci Rep. 2013;3:1673
pubmed: 23591719
Sci Signal. 2017 Oct 17;10(501):
pubmed: 29042481
J Biol Chem. 2003 Oct 17;278(42):40679-87
pubmed: 12909644
Cancer Immunol Res. 2019 Sep;7(9):1547-1561
pubmed: 31362997
PLoS One. 2019 Jul 5;14(7):e0218897
pubmed: 31276567
J Immunol. 2010 Sep 1;185(5):2998-3006
pubmed: 20675593
Cancer Res. 1998 Jul 15;58(14):3154-62
pubmed: 9679984
J Biol Chem. 2011 Apr 29;286(17):14991-5002
pubmed: 21343308
Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2646-54
pubmed: 27091975
Biochem Pharmacol. 2008 Feb 15;75(4):875-82
pubmed: 18068687
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10649-54
pubmed: 20498063
J Immunol. 2007 May 1;178(9):5930-9
pubmed: 17442977
Circ Res. 2004 Mar 5;94(4):462-70
pubmed: 14699013
Neoplasia. 2010 Mar;12(3):275-83
pubmed: 20234821
Int J Biochem Cell Biol. 2004 Jun;36(6):1115-25
pubmed: 15094126
Science. 2016 Apr 8;352(6282):227-31
pubmed: 26966191
J Biol Chem. 1999 Aug 6;274(32):22755-62
pubmed: 10428859
J Lab Clin Med. 1998 Dec;132(6):519-29
pubmed: 9851743
Hum Mol Genet. 2017 Dec 15;26(24):4951-4960
pubmed: 29206970
Cancer Res. 2004 Mar 1;64(5):1570-4
pubmed: 14996710
Am J Pathol. 1999 Aug;155(2):441-52
pubmed: 10433937
Thromb Haemost. 1994 Dec;72(6):787-92
pubmed: 7740442
Nat Rev Cancer. 2009 Mar;9(3):182-94
pubmed: 19194382
Matrix Biol. 2009 Mar;28(2):110-9
pubmed: 19284971
PLoS One. 2018 Aug 22;13(8):e0201832
pubmed: 30133535
Nucleic Acids Res. 2000 Jun 1;28(11):2268-75
pubmed: 10871348
Ann Surg. 2008 Jan;247(1):180-90
pubmed: 18156939
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15030-5
pubmed: 22927417
Aging Cell. 2020 Nov;19(11):e13236
pubmed: 33029941
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8
pubmed: 1697685
Clin Cancer Res. 2015 Sep 15;21(18):4184-93
pubmed: 25779942
Tumour Biol. 2008;29(1):28-34
pubmed: 18497546
J Exp Med. 2012 Dec 17;209(13):2441-53
pubmed: 23183047
Breast Cancer Res Treat. 2018 Nov;172(1):69-82
pubmed: 30056566
Int J Biochem Cell Biol. 2004 Jun;36(6):1038-45
pubmed: 15094119
Matrix Biol. 2014 Jul;37:15-24
pubmed: 24845346
Am J Pathol. 2008 Sep;173(3):879-91
pubmed: 18688033
Autophagy. 2012 Nov;8(11):1628-42
pubmed: 22874555
Am J Pathol. 2008 Oct;173(4):1100-12
pubmed: 18787106
Metabolites. 2019 Oct 08;9(10):
pubmed: 31597291
Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16266-71
pubmed: 17056717
Cancer Metastasis Rev. 2018 Sep;37(2-3):469-476
pubmed: 29909440
PLoS One. 2013 Nov 01;8(11):e78935
pubmed: 24223867
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4449-54
pubmed: 10200282
Cancer Res. 1997 May 1;57(9):1735-42
pubmed: 9135017
Curr Drug Targets. 2008 Oct;9(10):822-32
pubmed: 18855616
Biochem Biophys Res Commun. 2001 Aug 10;286(1):141-9
pubmed: 11485320
Cancer Res. 1994 Dec 15;54(24):6504-11
pubmed: 7527299
J Proteome Res. 2017 Jan 6;16(1):238-246
pubmed: 27728760
Am J Pathol. 2016 Mar;186(3):678-90
pubmed: 26801735
Nat Med. 2015 Oct;21(10):1209-15
pubmed: 26322579
Hepatology. 2019 Oct;70(4):1262-1279
pubmed: 30991448
Biomark Res. 2017 Aug 14;5:26
pubmed: 28815041
Anticancer Res. 2013 Apr;33(4):1429-38
pubmed: 23564783
J Clin Oncol. 2019 Apr 20;37(12):946-953
pubmed: 30811285
Neoplasia. 2008 Aug;10(8):886-96
pubmed: 18670646
Cancer Lett. 2019 Feb 1;442:287-298
pubmed: 30439539
J Cell Biol. 1997 Aug 11;138(3):707-17
pubmed: 9245797
J Clin Invest. 2016 Nov 1;126(11):4140-4156
pubmed: 27701147
Int J Biochem Cell Biol. 2016 Dec;81(Pt A):184-194
pubmed: 27163531
J Cell Physiol. 2020 Jan;235(1):364-379
pubmed: 31236971
Am J Clin Exp Urol. 2021 Feb 15;9(1):18-31
pubmed: 33816691
Mol Cancer. 2019 Mar 30;18(1):59
pubmed: 30925927
Cancer Cell. 2017 Feb 13;31(2):286-299
pubmed: 28196596
Int J Biochem Cell Biol. 2008;40(4):700-9
pubmed: 17996481
Nat Metab. 2020 Aug;2(8):703-716
pubmed: 32747793
Nat Rev Drug Discov. 2019 Sep;18(9):669-688
pubmed: 31363227
Cancer Immunol Immunother. 2019 Nov;68(11):1805-1817
pubmed: 31628526
J Immunol. 2003 Apr 1;170(7):3544-53
pubmed: 12646616
Nat Med. 2000 Jan;6(1):41-8
pubmed: 10613822
Cell Metab. 2014 Jul 1;20(1):61-72
pubmed: 24930970
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33416832
Aging Cell. 2020 Oct;19(10):e13224
pubmed: 32866348
J Immunol. 2008 Apr 1;180(7):4978-85
pubmed: 18354223
DNA Repair (Amst). 2015 Apr;28:107-15
pubmed: 25758781
Blood. 2007 Mar 1;109(5):1945-52
pubmed: 17082319
Biochemistry. 2003 Aug 26;42(33):10001-11
pubmed: 12924949
Atlas Genet Cytogenet Oncol Haematol. 2020;24(8):291-299
pubmed: 33244322
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73
pubmed: 23087362
Int J Biochem Cell Biol. 2008;40(9):1890-900
pubmed: 18321763
J Med Chem. 2016 Sep 22;59(18):8412-21
pubmed: 27526615
Antib Ther. 2020 Jul;3(3):179-192
pubmed: 33244513
Annu Rev Immunol. 2014;32:25-50
pubmed: 24215318
Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6689-95
pubmed: 18006769
Clin Exp Metastasis. 2005;22(3):215-23
pubmed: 16158249
Cancer Res. 2006 Jul 15;66(14):7216-24
pubmed: 16849569
Matrix Biol. 2005 Apr;24(2):110-23
pubmed: 15890262
Am J Pathol. 2002 Sep;161(3):831-9
pubmed: 12213711
J Biol Chem. 2000 Oct 13;275(41):31715-21
pubmed: 10922378
Oncotarget. 2017 Jul 11;8(48):84546-84558
pubmed: 29137447
Dev Cell. 2019 May 6;49(3):347-360
pubmed: 31063754
Mol Cell Proteomics. 2013 Aug;12(8):2148-59
pubmed: 23645497
Nat Immunol. 2020 Mar;21(3):298-308
pubmed: 32066953
Br Med Bull. 1997;53(3):491-508
pubmed: 9374033
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14016-21
pubmed: 19666525
Clin Cancer Res. 2009 Jun 1;15(11):3827-33
pubmed: 19435835
Matrix Biol. 2012 Apr;31(3):178-86
pubmed: 22266026
J Cell Sci. 2008 Mar 15;121(Pt 6):784-95
pubmed: 18285447
PLoS One. 2008;3(12):e3950
pubmed: 19079608
J Biol Chem. 1997 Mar 7;272(10):6784-91
pubmed: 9045712
Sci Rep. 2019 Jul 23;9(1):10608
pubmed: 31337788
J Cell Biol. 2002 Apr 29;157(3):509-19
pubmed: 11980922
J Cell Mol Med. 2018 Apr;22(4):2086-2097
pubmed: 29441713
Cell. 2009 Jul 23;138(2):286-99
pubmed: 19632179
J Biol Chem. 2009 Jan 9;284(2):1116-25
pubmed: 19004835
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):e1-e17
pubmed: 33232198
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2582-8
pubmed: 17916772
J Immunol. 2006 Sep 15;177(6):3534-41
pubmed: 16951312
J Cell Biol. 1990 Dec;111(6 Pt 2):3077-86
pubmed: 2269666
Sci Transl Med. 2010 Dec 22;2(63):63ra94
pubmed: 21178137
Proc Natl Acad Sci U S A. 2020 May 5;117(18):9896-9905
pubmed: 32321834
Crit Rev Biochem Mol Biol. 2015;50(3):212-30
pubmed: 25708195
J Cell Biol. 1987 Nov;105(5):2409-15
pubmed: 3680388
J Cell Biol. 1990 Aug;111(2):765-72
pubmed: 1696271
Ann Surg. 2008 May;247(5):860-8
pubmed: 18438125
PLoS One. 2009 Aug 31;4(8):e6840
pubmed: 19721725
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7
pubmed: 22451913
Cancer Res. 2016 Oct 1;76(19):5657-5670
pubmed: 27698188
Sci Transl Med. 2009 Oct 21;1(3):3ra7
pubmed: 20161613
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18342-7
pubmed: 22042861
Immunology. 2015 Apr;144(4):687-703
pubmed: 25393517
Am J Clin Oncol. 2007 Jun;30(3):303-9
pubmed: 17551310
Cardiovasc Res. 2016 Jan 1;109(1):115-30
pubmed: 26503986
Cell. 2009 Jul 23;138(2):271-85
pubmed: 19632178
J Clin Invest. 2013 Oct;123(10):4375-89
pubmed: 24018559
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11103-8
pubmed: 23690610
Cancers (Basel). 2019 Dec 05;11(12):
pubmed: 31817450
Front Pharmacol. 2015 Oct 29;6:252
pubmed: 26578962
Oncogene. 2013 Sep 12;32(37):4377-86
pubmed: 23085760
J Biol Chem. 2010 Dec 10;285(50):38923-32
pubmed: 20923780
Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):e350-e366
pubmed: 33028100
Blood. 2005 Jul 15;106(2):658-67
pubmed: 15784731
Discoveries (Craiova). 2014 Oct-Dec;2(4):
pubmed: 26273699
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Front Cell Dev Biol. 2019 Jan 29;7:4
pubmed: 30761299
Leukemia. 2012 Dec;26(12):2538-45
pubmed: 22648449
Am J Pathol. 1996 Jun;148(6):1851-60
pubmed: 8669471
J Biol Chem. 2015 Oct 9;290(41):24858-74
pubmed: 26311851
Biochem Biophys Res Commun. 1991 Jun 28;177(3):1087-94
pubmed: 2059199
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13141-6
pubmed: 16150726
Blood. 2006 Nov 1;108(9):3112-20
pubmed: 16835379
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23717-23720
pubmed: 32900953
Plast Reconstr Surg. 2009 Dec;124(6):1880-1889
pubmed: 19952644
Nat Rev Immunol. 2014 Jul;14(7):435-46
pubmed: 24962260
Mol Biol Cell. 2000 Sep;11(9):2885-900
pubmed: 10982388
Oncotarget. 2016 Jan 19;7(3):3084-97
pubmed: 26625211
Cancer Res. 2011 Feb 15;71(4):1374-84
pubmed: 21177380
Front Oncol. 2019 Oct 01;9:994
pubmed: 31632920