Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.


Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
01 06 2021
Historique:
pubmed: 1 5 2021
medline: 24 7 2021
entrez: 30 4 2021
Statut: ppublish

Résumé

Ataxia-telangiectasia mutated (ATM) kinase deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, whereas cardiac functional and biochemical parameters were measured 14 wk post-WD. hKO-WD mice exhibited rapid body weight gain at

Identifiants

pubmed: 33929897
doi: 10.1152/ajpheart.00990.2020
pmc: PMC8289354
doi:

Substances chimiques

Bax protein, mouse 0
Ccl3 protein, mouse 0
Ccl4 protein, mouse 0
Chemokine CCL3 0
Chemokine CCL4 0
Chemokines, CC 0
Collagen Type I 0
Collagen Type I, alpha 1 Chain 0
Glucose Transporter Type 4 0
IFNG protein, mouse 0
Slc2a4 protein, mouse 0
bcl-2-Associated X Protein 0
Interleukin-12 187348-17-0
Interferon-gamma 82115-62-6
Parp1 protein, mouse EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30
Ataxia Telangiectasia Mutated Proteins EC 2.7.11.1
Atm protein, mouse EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1
I-kappa B Kinase EC 2.7.11.10
Adenylate Kinase EC 2.7.4.3
Matrix Metalloproteinase 2 EC 3.4.24.24
Mmp2 protein, mouse EC 3.4.24.24
Matrix Metalloproteinase 9 EC 3.4.24.35
Mmp9 protein, mouse EC 3.4.24.35

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

H2324-H2338

Subventions

Organisme : U.S. Department of Veterans Affairs (VA)
ID : I01BX002332
Organisme : NHLBI NIH HHS
ID : R15 HL141947
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL156214
Pays : United States
Organisme : BLRD VA
ID : I01 BX004045
Pays : United States
Organisme : BLRD VA
ID : I01 BX002332
Pays : United States
Organisme : HHS | NIH | Office of Extramural Research, National Institutes of Health (OER)
ID : R15HL141947
Organisme : U.S. Department of Veterans Affairs (VA)
ID : I01BX004045

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Auteurs

Mary C Wingard (MC)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.

Suman Dalal (S)

Department of Health Sciences, East Tennessee State University, Johnson City, Tennessee.
Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee.

Paige L Shook (PL)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.

Rachel Myers (R)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.

Barbara A Connelly (BA)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
James H Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee.

Douglas P Thewke (DP)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.

Mahipal Singh (M)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.

Krishna Singh (K)

Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee.
James H Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee.

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Classifications MeSH