Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.

Animals Autistic Disorder / drug therapy DNA-Binding Proteins / deficiency Female Haploinsufficiency / drug effects Male Maze Learning / drug effects Mice Mice, Transgenic Oxytocin / pharmacology Social Behavior
Anxiety Autism CHD8 Oxytocin Social novelty

Journal

BMC neuroscience
ISSN: 1471-2202
Titre abrégé: BMC Neurosci
Pays: England
ID NLM: 100966986

Informations de publication

Date de publication:
01 05 2021
Historique:
received: 19 09 2020
accepted: 24 03 2021
entrez: 2 5 2021
pubmed: 3 5 2021
medline: 2 2 2022
Statut: epublish

Résumé

Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA binding protein 8 (CHD8), a gene encoding a chromatin remodeler. It has previously been shown that Chd8 haplodeficient male mice manifest ASD-like behavioral characteristics such as anxiety and altered social behavior. Along with that, oxytocin (OT) is one of the main neuropeptides involved in social behavior. Administration of OT has shown improvement of social behavior in genetic animal models of ASD. The present study was undertaken to further explore behavioral abnormalities of Chd8 haplodeficient mice of both sexes, their link with OT, and possible effects of OT administration. First, we performed a battery of behavioral tests on wild-type and Chd8 We showed general anxiety phenotype in Chd8 Here, we demonstrated that abnormal social behaviors were observed in both male and female Chd8

Sections du résumé

BACKGROUND
Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA binding protein 8 (CHD8), a gene encoding a chromatin remodeler. It has previously been shown that Chd8 haplodeficient male mice manifest ASD-like behavioral characteristics such as anxiety and altered social behavior. Along with that, oxytocin (OT) is one of the main neuropeptides involved in social behavior. Administration of OT has shown improvement of social behavior in genetic animal models of ASD. The present study was undertaken to further explore behavioral abnormalities of Chd8 haplodeficient mice of both sexes, their link with OT, and possible effects of OT administration. First, we performed a battery of behavioral tests on wild-type and Chd8
RESULTS
We showed general anxiety phenotype in Chd8
CONCLUSIONS
Here, we demonstrated that abnormal social behaviors were observed in both male and female Chd8

Identifiants

DOI: 10.1186/s12868-021-00631-6 PMID: 33933000 PMC: PMC8088024
pubmed: 33933000
doi: 10.1186/s12868-021-00631-6
pii: 10.1186/s12868-021-00631-6
pmc: PMC8088024
doi:

Substances chimiques

DNA-Binding Proteins 0
duplin protein, mouse 0
Oxytocin 50-56-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

32

Références

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Auteurs

Stanislav M Cherepanov (SM)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Maria Gerasimenko (M)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Teruko Yuhi (T)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Kazumi Furuhara (K)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Chiharu Tsuji (C)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Shigeru Yokoyama (S)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.

Keiichi I Nakayama (KI)

Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.

Masaaki Nishiyama (M)

Department of Histology and Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.

Haruhiro Higashida (H)

Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan. haruhiro@med.kanazawa-u.ac.jp.
ORCID: 0000-0002-1779-0606

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Dosage génique › Haploinsuffisance › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones post-hypophysaires › Ocytocine › Oxytocin ameliorates impaired social behavior...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › Oxytocin ameliorates impaired social behavior...