Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection.
ABO Blood-Group System
/ genetics
Angiotensin-Converting Enzyme 2
/ genetics
Apolipoprotein L1
/ genetics
Basigin
/ genetics
COVID-19
/ epidemiology
Dipeptidyl Peptidase 4
/ genetics
Endoplasmic Reticulum Chaperone BiP
Heat-Shock Proteins
/ genetics
Heme Oxygenase-1
/ genetics
Humans
Immunity
/ genetics
Neuropilin-1
/ genetics
Patient Outcome Assessment
Polymorphism, Genetic
Receptors, Calcitriol
/ genetics
SARS-CoV-2
Serine Endopeptidases
/ genetics
Vitamin D-Binding Protein
/ genetics
Vitamin K Epoxide Reductases
/ genetics
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
24
10
2020
accepted:
23
02
2021
pubmed:
3
5
2021
medline:
15
7
2021
entrez:
2
5
2021
Statut:
ppublish
Résumé
The SARS-CoV-2 pandemic has become one of the most serious health concerns globally. Although multiple vaccines have recently been approved for the prevention of coronavirus disease 2019 (COVID-19), an effective treatment is still lacking. Our knowledge of the pathogenicity of this virus is still incomplete. Studies have revealed that viral factors such as the viral load, duration of exposure to the virus, and viral mutations are important variables in COVID-19 outcome. Furthermore, host factors, including age, health condition, co-morbidities, and genetic background, might also be involved in clinical manifestations and infection outcome. This review focuses on the importance of variations in the host genetic background and pathogenesis of SARS-CoV-2. We will discuss the significance of polymorphisms in the ACE-2, TMPRSS2, vitamin D receptor, vitamin D binding protein, CD147, glucose-regulated protein 78 kDa, dipeptidyl peptidase-4 (DPP4), neuropilin-1, heme oxygenase, apolipoprotein L1, vitamin K epoxide reductase complex 1 (VKORC1), and immune system genes for the clinical outcome of COVID-19.
Identifiants
pubmed: 33934196
doi: 10.1007/s00705-021-05070-6
pii: 10.1007/s00705-021-05070-6
pmc: PMC8088757
doi:
Substances chimiques
ABO Blood-Group System
0
APOL1 protein, human
0
Apolipoprotein L1
0
BSG protein, human
0
Endoplasmic Reticulum Chaperone BiP
0
Heat-Shock Proteins
0
NRP1 protein, human
0
Receptors, Calcitriol
0
Vitamin D-Binding Protein
0
Basigin
136894-56-9
Neuropilin-1
144713-63-3
HMOX1 protein, human
EC 1.14.14.18
Heme Oxygenase-1
EC 1.14.14.18
VKORC1 protein, human
EC 1.17.4.4
Vitamin K Epoxide Reductases
EC 1.17.4.4
DPP4 protein, human
EC 3.4.14.5
Dipeptidyl Peptidase 4
EC 3.4.14.5
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Serine Endopeptidases
EC 3.4.21.-
TMPRSS2 protein, human
EC 3.4.21.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2089-2108Subventions
Organisme : Shiraz University of Medical Sciences
ID : 22169
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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