Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial.
RBC transfusion
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
10
03
2021
received:
03
08
2020
accepted:
23
03
2021
pubmed:
6
5
2021
medline:
23
7
2021
entrez:
5
5
2021
Statut:
ppublish
Résumé
The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences. The effects of two types of RCC (RCC-A, RCC-B) on transfusion regime were compared in a non-blinded, prospective, randomized, two-period, and crossover clinical trial. RCC-A was obtained by whole blood leukoreduction and subsequent plasma removal, RCC-B removing plasma and buffy coat first, followed by leukoreduction. Eligible patients were adult, with transfusion-dependent thalassemia (TDT). RCC-A contained 63.9 (60.3-67.8) grams of hemoglobin per unit (median with 1 To reduce the number of RCC units consumed per year and the number of transfusion episodes, TDT patients should receive RCC with the highest average hemoglobin content.
Sections du résumé
BACKGROUND
The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences.
STUDY DESIGN AND METHODS
The effects of two types of RCC (RCC-A, RCC-B) on transfusion regime were compared in a non-blinded, prospective, randomized, two-period, and crossover clinical trial. RCC-A was obtained by whole blood leukoreduction and subsequent plasma removal, RCC-B removing plasma and buffy coat first, followed by leukoreduction. Eligible patients were adult, with transfusion-dependent thalassemia (TDT).
RESULTS
RCC-A contained 63.9 (60.3-67.8) grams of hemoglobin per unit (median with 1
CONCLUSION
To reduce the number of RCC units consumed per year and the number of transfusion episodes, TDT patients should receive RCC with the highest average hemoglobin content.
Identifiants
pubmed: 33948969
doi: 10.1111/trf.16432
pmc: PMC8252500
doi:
Substances chimiques
Hemoglobins
0
Types de publication
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1729-1739Subventions
Organisme : Associazione per la Lotta alla Talassemia Rino Vullo di Ferrara
Organisme : Centro Regionale Sangue della regione Emilia-Romagna
Informations de copyright
© 2021 The Authors. Transfusion published by Wiley Periodicals LLC. on behalf of AABB.
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