Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
05 05 2021
05 05 2021
Historique:
received:
26
07
2020
revised:
01
12
2020
accepted:
14
04
2021
entrez:
6
5
2021
pubmed:
7
5
2021
medline:
13
7
2021
Statut:
ppublish
Résumé
Estimating the time of delivery is of high clinical importance because pre- and postterm deviations are associated with complications for the mother and her offspring. However, current estimations are inaccurate. As pregnancy progresses toward labor, major transitions occur in fetomaternal immune, metabolic, and endocrine systems that culminate in birth. The comprehensive characterization of maternal biology that precedes labor is key to understanding these physiological transitions and identifying predictive biomarkers of delivery. Here, a longitudinal study was conducted in 63 women who went into labor spontaneously. More than 7000 plasma analytes and peripheral immune cell responses were analyzed using untargeted mass spectrometry, aptamer-based proteomic technology, and single-cell mass cytometry in serial blood samples collected during the last 100 days of pregnancy. The high-dimensional dataset was integrated into a multiomic model that predicted the time to spontaneous labor [
Identifiants
pubmed: 33952678
pii: 13/592/eabd9898
doi: 10.1126/scitranslmed.abd9898
pmc: PMC8136601
mid: NIHMS1702602
pii:
doi:
Substances chimiques
Biomarkers
0
Proteome
0
Banques de données
Dryad
['10.5061/dryad.280gb5mpd']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM137936
Pays : United States
Organisme : NINDS NIH HHS
ID : R61 NS114926
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM099608
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM138353
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058417
Pays : United States
Organisme : Doris Duke Charitable Foundation
ID : 2018100
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139844
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Nat Med. 2013 May;19(5):548-56
pubmed: 23652115
Facts Views Vis Obgyn. 2012;4(3):175-87
pubmed: 24753906
J Clin Endocrinol Metab. 1996 Sep;81(9):3328-34
pubmed: 8784092
PLoS One. 2015 Sep 23;10(9):e0137188
pubmed: 26397719
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Sci Immunol. 2017 Sep 1;2(15):
pubmed: 28864494
Int J Gynaecol Obstet. 2004 Oct;87(1):38-9
pubmed: 15464776
Clin Nephrol. 2011 Sep;76(3):174-9
pubmed: 21888853
J Clin Immunol. 2012 Apr;32(2):300-11
pubmed: 22198680
Placenta. 1997 Mar-Apr;18(2-3):197-204
pubmed: 9089782
Front Microbiol. 2020 Apr 08;11:476
pubmed: 32322240
Am J Obstet Gynecol. 2018 Mar;218(3):347.e1-347.e14
pubmed: 29277631
Mol Cell Proteomics. 2015 Jun;14(6):1684-95
pubmed: 25787789
Mol Hum Reprod. 2015 Jan;21(1):81-94
pubmed: 25237006
Reprod Sci. 2013 Feb;20(2):154-67
pubmed: 22614625
Eur J Obstet Gynecol Reprod Biol. 2008 Jan;136(1):16-9
pubmed: 17275981
Adv Exp Med Biol. 2003;527:757-60
pubmed: 15206800
J Clin Endocrinol Metab. 2010 Jul;95(7):3428-36
pubmed: 20410222
Cell. 2020 Jun 25;181(7):1680-1692.e15
pubmed: 32589958
J Clin Endocrinol Metab. 1972 Dec;35(6):799-808
pubmed: 4634481
Semin Immunopathol. 2020 Aug;42(4):397-412
pubmed: 32020337
Nat Med. 1995 May;1(5):460-3
pubmed: 7585095
Am J Perinatol. 2017 Sep;34(11):1078-1083
pubmed: 28605823
Transfusion. 2004 Apr;44(4):581-5
pubmed: 15043575
Front Immunol. 2019 Jun 11;10:1305
pubmed: 31263463
Am J Hypertens. 2009 Aug;22(8):891-5
pubmed: 19478794
Am J Obstet Gynecol. 2017 Jul;217(1):67.e1-67.e21
pubmed: 28263753
Nat Med. 2019 Jun;25(6):1012-1021
pubmed: 31142849
Cell Cycle. 2017;16(21):2023-2031
pubmed: 28873006
Obstet Gynecol Sci. 2019 Jul;62(4):199-211
pubmed: 31338337
Cell. 2009 Jul 23;138(2):389-403
pubmed: 19615732
J Clin Endocrinol Metab. 2012 Aug;97(8):E1370-9
pubmed: 22685232
J Leukoc Biol. 2002 Nov;72(5):874-84
pubmed: 12429709
Nat Mach Intell. 2020 Oct;2(10):619-628
pubmed: 33294774
Front Endocrinol (Lausanne). 2019 Mar 29;10:198
pubmed: 30984115
J Clin Endocrinol Metab. 2002 Sep;87(9):4213-24
pubmed: 12213874
J Reprod Immunol. 2018 Apr;126:1-10
pubmed: 29367099
J Matern Fetal Neonatal Med. 2018 Feb;31(4):418-432
pubmed: 28114842
Front Immunol. 2020 Mar 17;11:452
pubmed: 32256497
Ann Rheum Dis. 2000 Jul;59(7):555-64
pubmed: 10873967
Nat Immunol. 2015 Apr;16(4):328-34
pubmed: 25789673
J Reprod Immunol. 2018 Aug;128:30-37
pubmed: 29886307
Reprod Sci. 2013 Jun;20(6):646-53
pubmed: 23171684
J Soc Gynecol Investig. 2003 May;10(4):231-6
pubmed: 12759152
JCI Insight. 2020 Apr 9;5(7):
pubmed: 32163376
Bioinformatics. 2019 Jan 1;35(1):95-103
pubmed: 30561547
Am J Obstet Gynecol. 2002 Dec;187(6):1660-6
pubmed: 12501080
Aging (Albany NY). 2016 Feb;8(2):216-30
pubmed: 26851389
PLoS One. 2019 Jun 4;14(6):e0217273
pubmed: 31163045
Nat Protoc. 2015 Feb;10(2):316-33
pubmed: 25612231
PLoS One. 2010 Dec 07;5(12):e15004
pubmed: 21165148
PLoS One. 2011;6(9):e24463
pubmed: 21949719
Lancet. 2017 Dec 17;388(10063):3027-3035
pubmed: 27839855
Glycobiology. 2007 Sep;17(9):922-31
pubmed: 17580316
Nat Rev Immunol. 2017 Aug;17(8):483-494
pubmed: 28480895
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S173-81
pubmed: 26428497
Cytometry A. 2013 May;83(5):483-94
pubmed: 23512433
Mucosal Immunol. 2014 Mar;7(2):348-58
pubmed: 23945545
Am J Obstet Gynecol. 2016 May;214(5):633.e1-633.e24
pubmed: 26874297
Mol Cell Biol. 2001 Apr;21(8):2906-17
pubmed: 11283268
Dis Markers. 2015;2015:435014
pubmed: 26160993
Semin Fetal Neonatal Med. 2019 Feb;24(1):27-32
pubmed: 30337215
Am J Obstet Gynecol. 1981 Feb 15;139(4):416-22
pubmed: 6258436
Cell Mol Immunol. 2014 Nov;11(6):571-81
pubmed: 24954221
Front Immunol. 2017 Sep 15;8:1138
pubmed: 28966619
Lancet. 1997 Aug 16;350(9076):485-7
pubmed: 9274585
Mol Endocrinol. 2009 Jul;23(7):947-54
pubmed: 19282364
Placenta. 2019 Apr;79:40-45
pubmed: 30454905
Science. 2018 Jun 8;360(6393):1133-1136
pubmed: 29880692
Semin Reprod Med. 2007 Jan;25(1):5-13
pubmed: 17205419
Mol Ther Nucleic Acids. 2014 Oct 07;3:e201
pubmed: 25291143
Steroids. 2015 Mar;95:24-31
pubmed: 25541057
Am J Obstet Gynecol. 2011 Apr;204(4):364.e9-16
pubmed: 21296334
Thromb Res. 2014 Sep;134(3):648-51
pubmed: 25087890
Elife. 2019 Dec 12;8:
pubmed: 31829938
N Engl J Med. 1999 Aug 26;341(9):660-6
pubmed: 10460818
J Matern Fetal Neonatal Med. 2008 Aug;21(8):529-47
pubmed: 18609361
Bioinformatics. 2007 Feb 15;23(4):401-7
pubmed: 17182697
Front Immunol. 2019 Dec 17;10:2863
pubmed: 31921132
Sci Rep. 2019 Jan 29;9(1):848
pubmed: 30696862
Nucleic Acids Res. 2015 Jul 1;43(W1):W251-7
pubmed: 25897128
Obstet Gynecol. 2017 May;129(5):e150-e154
pubmed: 28426621
Knowl Inf Syst. 2017 May;51(2):339-367
pubmed: 28603327
Nat Med. 2017 Jan;23(1):128-135
pubmed: 27918564
Obstet Gynecol. 2009 Dec;114(6):1326-1331
pubmed: 19935037