Environmental robustness of the global yeast genetic interaction network.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
07 05 2021
07 05 2021
Historique:
received:
23
11
2020
accepted:
30
03
2021
entrez:
7
5
2021
pubmed:
8
5
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions and scored 30,000 functionally representative yeast gene pairs for dynamic, differential interactions. Different conditions revealed novel differential interactions, which often uncovered functional connections between distantly related gene pairs. However, the majority of observed genetic interactions remained unchanged in different conditions, suggesting that the global yeast genetic interaction network is robust to environmental perturbation and captures the fundamental functional architecture of a eukaryotic cell.
Identifiants
pubmed: 33958448
pii: 372/6542/eabf8424
doi: 10.1126/science.abf8424
pmc: PMC9132594
mid: NIHMS1801409
pii:
doi:
Substances chimiques
Saccharomyces cerevisiae Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHGRI NIH HHS
ID : R01 HG005084
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG005853
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Nat Genet. 2017 Apr;49(4):497-503
pubmed: 28250458
G3 (Bethesda). 2015 Jul 14;5(9):1879-87
pubmed: 26175450
PLoS Genet. 2012;8(3):e1002590
pubmed: 22438835
BMC Genomics. 2006 Jul 25;7:187
pubmed: 16869964
Biochem Soc Trans. 2005 Jun;33(Pt 3):433-8
pubmed: 15916535
Science. 2001 Dec 14;294(5550):2364-8
pubmed: 11743205
Science. 2016 Sep 23;353(6306):
pubmed: 27708008
Nature. 2012 Sep 27;489(7417):585-9
pubmed: 22940862
Cell. 2017 Jul 27;170(3):564-576.e16
pubmed: 28753430
Nat Rev Mol Cell Biol. 2009 Jun;10(6):398-409
pubmed: 19436320
Genetics. 2013 Feb;193(2):383-410
pubmed: 23396477
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Mol Cell. 2013 Jan 24;49(2):346-58
pubmed: 23273983
Genetics. 2012 Nov;192(3):775-818
pubmed: 23135325
Nat Biotechnol. 2011 Apr;29(4):361-7
pubmed: 21441928
Bioinformatics. 2006 Dec 1;22(23):2890-7
pubmed: 17005538
Science. 2016 Nov 4;354(6312):
pubmed: 27811238
Cell. 1983 Apr;32(4):1026-8
pubmed: 6340834
Nature. 2003 Oct 16;425(6959):686-91
pubmed: 14562095
Science. 2010 Jan 22;327(5964):425-31
pubmed: 20093466
J Biol Chem. 2001 Sep 14;276(37):34537-44
pubmed: 11445562
Science. 2008 Jun 13;320(5882):1465-70
pubmed: 18467557
Cell Rep. 2017 Sep 12;20(11):2735-2748
pubmed: 28903051
Genetics. 2012 Mar;190(3):855-83
pubmed: 22419078
Mol Cell. 2017 Feb 16;65(4):761-774.e5
pubmed: 28132844
Mol Syst Biol. 2015 Apr 17;11(4):800
pubmed: 25888283
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3461-6
pubmed: 18305163
Nature. 2013 Feb 14;494(7436):234-7
pubmed: 23376951
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8
pubmed: 22223662
Nat Methods. 2010 Dec;7(12):1017-24
pubmed: 21076421
Genome Res. 2019 Apr;29(4):668-681
pubmed: 30782640
Cell. 2019 Mar 21;177(1):85-100
pubmed: 30901552
Nature. 2006 Mar 30;440(7084):637-43
pubmed: 16554755
Nucleic Acids Res. 2012 Jan;40(Database issue):D700-5
pubmed: 22110037
Methods Mol Biol. 2014;1205:143-68
pubmed: 25213244
PLoS Genet. 2016 Nov 3;12(11):e1006421
pubmed: 27812106
Nat Commun. 2015 Nov 05;6:8712
pubmed: 26537231
Science. 2008 Oct 3;322(5898):104-10
pubmed: 18719252
Science. 2005 Sep 30;309(5744):2185-9
pubmed: 16195452
Science. 2014 Apr 11;344(6180):208-11
pubmed: 24723613
Nature. 2006 Mar 30;440(7084):631-6
pubmed: 16429126
Nat Commun. 2019 Sep 19;10(1):4274
pubmed: 31537791
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
G3 (Bethesda). 2017 May 5;7(5):1539-1549
pubmed: 28325812
Genome Biol. 2012 Dec 26;13(12):R123
pubmed: 23268787
Acta Biochim Pol. 2008;55(4):649-62
pubmed: 19039336
Science. 2018 Apr 20;360(6386):
pubmed: 29674565
Nat Genet. 2007 Feb;39(2):199-206
pubmed: 17206143
Nature. 2002 Jul 25;418(6896):387-91
pubmed: 12140549
Nucleic Acids Res. 2019 Jan 8;47(D1):D550-D558
pubmed: 30357405
Science. 2004 Feb 6;303(5659):808-13
pubmed: 14764870
Mol Biol Cell. 2000 Dec;11(12):4241-57
pubmed: 11102521
Nature. 2002 Jun 6;417(6889):618-24
pubmed: 12050657
Science. 1999 Aug 6;285(5429):901-6
pubmed: 10436161
Genome Biol. 2012 Jul 02;13(7):R57
pubmed: 22747640
Annu Rev Cell Dev Biol. 2004;20:559-91
pubmed: 15473852
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5045-5054
pubmed: 30804202
Cell Syst. 2016 Jun 22;2(6):412-21
pubmed: 27237738
Biochemistry. 1979 Nov 13;18(23):5191-6
pubmed: 497177
Nat Genet. 2017 Dec;49(12):1779-1784
pubmed: 29083409
Nucleic Acids Res. 2011 Jan;39(Database issue):D698-704
pubmed: 21071413
Science. 2010 Dec 3;330(6009):1385-9
pubmed: 21127252
Science. 2002 May 3;296(5569):907-10
pubmed: 11988574
PLoS Genet. 2017 Sep 28;13(9):e1006973
pubmed: 28957314
Front Cell Dev Biol. 2016 Mar 30;4:20
pubmed: 27066478
Nat Commun. 2018 Sep 17;9(1):3548
pubmed: 30224702