Multivariate approach for longitudinal analysis of brain metabolite levels from ages 5-11 years in children with perinatal HIV infection.
Basal Ganglia
/ diagnostic imaging
Child
Child Development
/ physiology
Child, Preschool
Female
Gray Matter
/ diagnostic imaging
HIV Infections
/ diagnostic imaging
Humans
Infectious Disease Transmission, Vertical
Longitudinal Studies
Magnetic Resonance Spectroscopy
/ methods
Male
Neuroimaging
/ methods
White Matter
/ diagnostic imaging
Brain metabolites
Correlated response model (CRM)
Longitudinal analysis
Magnetic resonance spectroscopy (MRS)
Multilevel mixed effect model (MMEM)
Perinatal HIV infection
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 08 2021
15 08 2021
Historique:
received:
01
11
2020
revised:
16
03
2021
accepted:
19
04
2021
pubmed:
8
5
2021
medline:
29
10
2021
entrez:
7
5
2021
Statut:
ppublish
Résumé
Treatment guidelines recommend that children with perinatal HIV infection (PHIV) initiate antiretroviral therapy (ART) early in life and remain on it lifelong. As part of a longitudinal study examining the long-term consequences of PHIV and early ART on the developing brain, 89 PHIV children and a control group of 85 HIV uninfected children (HIV-) received neuroimaging at ages 5, 7, 9 and 11 years, including single voxel magnetic resonance spectroscopy (MRS) in three brain regions, namely the basal ganglia (BG), midfrontal gray matter (MFGM) and peritrigonal white matter (PWM). We analysed age-related changes in absolute metabolite concentrations using a multivariate approach traditionally applied to ecological data, the Correlated Response Model (CRM) and compared these to results obtained from a multilevel mixed effect modelling (MMEM) approach. Both approaches produce similar outcomes in relation to HIV status and age effects on longitudinal trajectories. Both methods found similar age-related increases in both PHIV and HIV- children in almost all metabolites across regions. We found significantly elevated GPC+PCh across regions (95% CI=[0.033; 0.105] in BG; 95% CI=[0.021; 0.099] in PWM; 95% CI=[0.059; 0.137] in MFGM) and elevated mI in MFGM (95% CI=[0.131; 0.407]) among children living with PHIV compared to HIV- children; additionally the CRM model also indicated elevated mI in BG (95% CI=[0.008; 0.248]). These findings suggest persistent inflammation across the brain in young children living with HIV despite early ART initiation.
Identifiants
pubmed: 33961998
pii: S1053-8119(21)00378-5
doi: 10.1016/j.neuroimage.2021.118101
pmc: PMC8295244
mid: NIHMS1723748
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
118101Subventions
Organisme : NICHD NIH HHS
ID : R01 HD099846
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH096559
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH108346
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicting financial interests to declare.
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