Capturing T Lymphocytes' Dynamic Interactions With Human Neural Cells Using Time-Lapse Microscopy.
Adult
Astrocytes
/ drug effects
CD8-Positive T-Lymphocytes
/ immunology
Cell Communication
/ drug effects
Cell Movement
Cells, Cultured
Coculture Techniques
Female
Histocompatibility Antigens Class I
/ immunology
Humans
Inflammation
/ immunology
Interleukin-1beta
/ pharmacology
Male
Microscopy, Video
Middle Aged
Neurons
/ drug effects
Phenotype
Time Factors
Time-Lapse Imaging
Young Adult
MHC class I
astrocytes
inflammation
live imaging
neurons
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
02
2021
accepted:
29
03
2021
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
21
10
2021
Statut:
epublish
Résumé
To fully perform their functions, T lymphocytes migrate within organs' parenchyma and interact with local cells. Infiltration of T lymphocytes within the central nervous system (CNS) is associated with numerous neurodegenerative disorders. Nevertheless, how these immune cells communicate and respond to neural cells remains unresolved. To investigate the behavior of T lymphocytes that reach the CNS, we have established an
Identifiants
pubmed: 33968073
doi: 10.3389/fimmu.2021.668483
pmc: PMC8100528
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
IL1B protein, human
0
Interleukin-1beta
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
668483Informations de copyright
Copyright © 2021 Lemaître, Carmena Moratalla, Farzam-kia, Carpentier Solorio, Tastet, Cleret-Buhot, Guimond, Haddad and Arbour.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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