The cytochrome P450 (CYP) superfamily in cnidarians.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 05 2021
10 05 2021
Historique:
received:
29
09
2020
accepted:
15
04
2021
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
26
10
2021
Statut:
epublish
Résumé
The cytochrome P450 (CYP) superfamily is a diverse and important enzyme family, playing a central role in chemical defense and in synthesis and metabolism of major biological signaling molecules. The CYPomes of four cnidarian genomes (Hydra vulgaris, Acropora digitifera, Aurelia aurita, Nematostella vectensis) were annotated; phylogenetic analyses determined the evolutionary relationships amongst the sequences and with existing metazoan CYPs. 155 functional CYPs were identified and 90 fragments. Genes were from 24 new CYP families and several new subfamilies; genes were in 9 of the 12 established metazoan CYP clans. All species had large expansions of clan 2 diversity, with H. vulgaris having reduced diversity for both clan 3 and mitochondrial clan. We identified potential candidates for xenobiotic metabolism and steroidogenesis. That each genome contained multiple, novel CYP families may reflect the large evolutionary distance within the cnidarians, unique physiology in the cnidarian classes, and/or different ecology of the individual species.
Identifiants
pubmed: 33972594
doi: 10.1038/s41598-021-88700-y
pii: 10.1038/s41598-021-88700-y
pmc: PMC8110760
doi:
Substances chimiques
Xenobiotics
0
Cytochrome P-450 Enzyme System
9035-51-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9834Subventions
Organisme : NHGRI NIH HHS
ID : U24 HG003345
Pays : United States
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