Effects of a β2-adrenergic receptor blocker on experimental periodontitis in spontaneously hypertensive rats.
Adrenergic beta-2 Receptor Antagonists
/ pharmacology
Alveolar Bone Loss
/ metabolism
Animals
Blood Pressure
/ drug effects
Bone Density
/ drug effects
Bone and Bones
/ drug effects
Butoxamine
/ metabolism
Female
Hypertension
/ metabolism
Male
Osteoclasts
/ drug effects
Periodontitis
/ drug therapy
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Adrenergic
/ metabolism
Receptors, Adrenergic, beta-2
/ metabolism
Sympathetic Nervous System
/ drug effects
X-Ray Microtomography
/ methods
Beta-2 adrenergic receptor
Butoxamine
Osteoclast
Periodontitis
Spontaneously hypertensive rats
Sympathetic nervous system
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
15
12
2020
revised:
22
04
2021
accepted:
01
05
2021
pubmed:
13
5
2021
medline:
23
6
2021
entrez:
12
5
2021
Statut:
ppublish
Résumé
Recent studies have reported a relationship between periodontal disease and hypertension, and previous evidence suggests that the sympathetic nervous system plays an important role in the control of bone metabolism. This study sought to evaluate the effect of the beta-2 adrenergic receptor (β2-AR) blocker butoxamine on experimental periodontitis in a rat model. Wistar-Kyoto and spontaneously hypertensive rats (n = 6 per group) were orally administered butoxamine 1 mg/kg/day and experimental periodontitis was induced by applying an orthodontic ligature wire. The rats were sacrificed after 4 weeks and the residual alveolar bone was measured using micro-computed tomography (micro-CT) imaging analysis software for histological analysis. Micro-CT imaging analysis showed a higher ratio of residual alveolar bone, BV/TV, and Tb.N in both Wistar-Kyoto and spontaneously hypertensive rats treated with butoxamine compared with the corresponding control rats. In histological analysis, compared with the Wistar-Kyoto and spontaneously hypertensive rat control groups, the corresponding butoxamine-treated groups showed a lower ratio of attachment level, lower values of osteoclast number and surface. β2-AR blockers maintained the alveolar bone mass and attachment level by suppressing osteoclast activity. Thus, β2-AR blockers may be effective in preventing periodontitis.
Identifiants
pubmed: 33979569
pii: S0024-3205(21)00579-8
doi: 10.1016/j.lfs.2021.119593
pii:
doi:
Substances chimiques
Adrenergic beta-2 Receptor Antagonists
0
Receptors, Adrenergic
0
Receptors, Adrenergic, beta-2
0
Butoxamine
0NM31M53PW
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119593Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.