Protein acetylation in the critical biological processes in protozoan parasites.
KATs
KDACs
acetylation
acetylome
bromodomain
glycolysis
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
01
02
2021
revised:
13
04
2021
accepted:
14
04
2021
pubmed:
18
5
2021
medline:
2
10
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
Protein lysine acetylation has emerged as a major regulatory post-translational modification in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone proteins involved in several cellular processes. The same scenario was observed in protozoan parasites after the description of their acetylomes, indicating that acetylation might regulate crucial biological processes in these parasites. The demonstration that glycolytic enzymes are regulated by acetylation in protozoans shows that this modification might regulate several other processes implicated in parasite survival and adaptation during the life cycle, opening the chance to explore the regulatory acetylation machinery of these parasites as drug targets for new treatment development.
Identifiants
pubmed: 33994102
pii: S1471-4922(21)00088-X
doi: 10.1016/j.pt.2021.04.008
pmc: PMC9515972
mid: NIHMS1834012
pii:
doi:
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
815-830Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM113131
Pays : United States
Organisme : Medical Research Council
ID : MR/P027989/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019472/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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