How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism.
alpha
beta
epilepsy
inhibition
interictal epileptiform discharges
magnetoencephalography
oscillations
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
received:
15
02
2021
accepted:
05
03
2021
pubmed:
19
5
2021
medline:
9
3
2022
entrez:
18
5
2021
Statut:
ppublish
Résumé
Interactions between interictal epileptiform discharges (IEDs) and distant cortical regions subserve potential effects on cognition of patients with focal epilepsy. We hypothesize that "healthy" brain areas at a distance from the epileptic focus may respond to the interference of IEDs by generating inhibitory alpha and beta oscillations. We predict that more prominent alpha-beta oscillations can be found in patients with less impaired neurocognitive profile. We performed a source imaging magnetoencephalography study, including 41 focal epilepsy patients: 21 with frontal lobe epilepsy (FLE) and 20 with mesial temporal lobe epilepsy. We investigated the effect of anterior (i.e., frontal and temporal) IEDs on the oscillatory pattern over posterior head regions. We compared cortical oscillations (5-80 Hz) temporally linked to 3,749 IEDs (1,945 frontal and 1,803 temporal) versus an equal number of IED-free segments. We correlated results from IED triggered oscillations to global neurocognitive performance. Only frontal IEDs triggered alpha-beta oscillations over posterior head regions. IEDs with higher amplitude triggered alpha-beta oscillations of higher magnitude. The intensity of posterior head region alpha-beta oscillations significantly correlated with a better neuropsychological profile. Our study demonstrated that cerebral cortex protects itself from IEDs with generation of inhibitory alpha-beta oscillations at distant cortical regions. The association of more prominent oscillations with a better cognitive status suggests that this mechanism might play a role in determining the cognitive resilience in patients with FLE.
Identifiants
pubmed: 34002916
doi: 10.1002/hbm.25422
pmc: PMC8249896
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3352-3365Subventions
Organisme : CIHR
ID : MOP-159948
Pays : Canada
Organisme : CIHR
ID : MOP-133619
Pays : Canada
Organisme : CIHR
ID : MOP-93614
Pays : Canada
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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