Association of single-nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes.
Adolescent
Adult
Aged
Alleles
Child
Child, Preschool
Diabetes Mellitus, Type 1
/ genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
HLA Antigens
/ genetics
Haplotypes
/ genetics
Humans
Infant
Interleukin-1
/ genetics
Interleukin-12
/ genetics
Interleukin-2
/ genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
/ genetics
Toll-Like Receptors
/ genetics
Tumor Necrosis Factor-alpha
/ genetics
Young Adult
IL-1R
Saudi population
single-nucleotide polymorphisms
tumour necrosis factor
type 1 diabetes
Journal
International journal of immunogenetics
ISSN: 1744-313X
Titre abrégé: Int J Immunogenet
Pays: England
ID NLM: 101232337
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
03
02
2021
received:
11
01
2020
accepted:
22
02
2021
pubmed:
22
5
2021
medline:
12
10
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive destruction of insulin-producing pancreatic beta cells. This multifactorial disease has a strong genetic component associated with the human leukocyte antigens (HLA) and non-HLA regions. In this study, we compared frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) associated the genes coding for: toll-like receptors (TLRs), tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-1 receptor type 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D patients and healthy controls. The aim was to identify frequency differences and linkage between these genetic markers in T1D patients and healthy controls. Twelve SNPs were investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF). TaqMan genotype assay method was used for SNPs genotyping. HLA-DRB1* genes were typed by Sequence Specific Oligonucleotide Probe (SSOP). SPSS and SNPStats programs were used for the statistical analysis. Significant differences between T1D and control groups were found for the dominant model of rs361525 and rs1800629A:rs361525G genotypes for TNF. Increased frequencies of DRB1*03 and DRB1*04 and decreased frequencies of DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 were observed in T1D patients compared with controls. However, the genotype, DRB1*07 with rs1800629A/G was associated with T1D. We have confirmed that DRB1*03 and DRB1*04 are associated with increased risk and DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 with decreased risk of T1D. Also, the dominant model of rs361525A, and the rs1800629G:361525A genotype were associated with increased risk. The simultaneous presence of DRB1*07 and rs1800629A/G genotypes in 23 out of 27 DRB1*07 positive T1D patients implied that islet cell peptide processing may have been biased towards autoimmunity by upregulation of TNF associated intronic SNPs.
Substances chimiques
HLA Antigens
0
Interleukin-1
0
Interleukin-2
0
Toll-Like Receptors
0
Tumor Necrosis Factor-alpha
0
Interleukin-12
187348-17-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-335Subventions
Organisme : King Fahad Medical City
ID : 017-034
Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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