Molecular epidemiology of NDM-5-producing Escherichia coli high-risk clones identified in two Italian hospitals in 2017-2019.
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
/ pharmacology
DNA, Bacterial
/ genetics
Disease Outbreaks
/ prevention & control
Drug Resistance, Multiple, Bacterial
Escherichia coli
/ drug effects
Escherichia coli Infections
/ epidemiology
Female
Genome, Bacterial
Hospitals
/ statistics & numerical data
Humans
Italy
/ epidemiology
Male
Microbial Sensitivity Tests
Middle Aged
Retrospective Studies
Whole Genome Sequencing
beta-Lactamases
/ biosynthesis
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
25
10
2020
revised:
09
03
2021
accepted:
12
04
2021
pubmed:
25
5
2021
medline:
6
11
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
Between November 2018 and October 2019, carbapenem-resistant Enterobacterales carrying New Delhi Metallo-β-lactamase (NDM) caused one of the largest and persistent outbreaks occurred in Italy and intensified surveillance measures have been taken in all Italian hospitals. In this study we analyzed NDM-5- producing Escherichia coli identified in 2 hospitals of the Lazio region in Italy. Epidemiological and microbiological data demonstrated that in 2018-2019 the NDM-5-producing high-risk E. coli ST167 clone circulated in patients from both hospitals. In 2019, another NDM-5-producing E. coli clone, identified by MLST as ST617 was introduced in one of the 2 hospitals and caused an outbreak. This study describes an application of genomics as a useful method to discern endemic and outbreak clones when applied to strains of the same species (E. coli) with the same resistance determinant (NDM-5) and the relevance of screening patients admitted in critical units for carbapenemase producers to prevent outbreaks.
Identifiants
pubmed: 34030105
pii: S0732-8893(21)00092-4
doi: 10.1016/j.diagmicrobio.2021.115399
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
DNA, Bacterial
0
beta lactamase NDM-5, E coli
EC 3.5.2.6
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115399Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Authors have no conflict of interest to declare with respect to the content of this paper