Immunopeptidomics for next-generation bacterial vaccine development.
MHC
antigen discovery
bacteria
infection
mass spectrometry
vaccine development
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
11
03
2021
revised:
28
04
2021
accepted:
30
04
2021
pubmed:
26
5
2021
medline:
8
4
2022
entrez:
25
5
2021
Statut:
ppublish
Résumé
Antimicrobial resistance is an increasing global threat and alternative treatments substituting failing antibiotics are urgently needed. Vaccines are recognized as highly effective tools to mitigate antimicrobial resistance; however, the selection of bacterial antigens as vaccine candidates remains challenging. In recent years, advances in mass spectrometry-based proteomics have led to the development of so-called immunopeptidomics approaches that allow the untargeted discovery of bacterial epitopes that are presented on the surface of infected cells. Especially for intracellular bacterial pathogens, immunopeptidomics holds great promise to uncover antigens that can be encoded in viral vector- or nucleic acid-based vaccines. This review provides an overview of immunopeptidomics studies on intracellular bacterial pathogens and considers future directions and challenges in advancing towards next-generation vaccines.
Identifiants
pubmed: 34030969
pii: S0966-842X(21)00121-9
doi: 10.1016/j.tim.2021.04.010
pii:
doi:
Substances chimiques
Antigens, Bacterial
0
Bacterial Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1034-1045Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests There are no interests to declare.