Light-based methods for predicting circadian phase in delayed sleep-wake phase disorder.

Adolescent Adult Biomarkers Circadian Rhythm Female Humans Light Male Middle Aged Prognosis Sensitivity and Specificity Sleep Sleep Disorders, Circadian Rhythm / diagnosis Trauma Severity Indices Young Adult

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
25 05 2021
Historique:
received: 04 02 2020
accepted: 13 04 2021
entrez: 26 5 2021
pubmed: 27 5 2021
medline: 4 11 2021
Statut: epublish

Résumé

Methods for predicting circadian phase have been developed for healthy individuals. It is unknown whether these methods generalize to clinical populations, such as delayed sleep-wake phase disorder (DSWPD), where circadian timing is associated with functional outcomes. This study evaluated two methods for predicting dim light melatonin onset (DLMO) in 154 DSWPD patients using ~ 7 days of sleep-wake and light data: a dynamic model and a statistical model. The dynamic model has been validated in healthy individuals under both laboratory and field conditions. The statistical model was developed for this dataset and used a multiple linear regression of light exposure during phase delay/advance portions of the phase response curve, as well as sleep timing and demographic variables. Both models performed comparably well in predicting DLMO. The dynamic model predicted DLMO with root mean square error of 68 min, with predictions accurate to within ± 1 h in 58% of participants and ± 2 h in 95%. The statistical model predicted DLMO with root mean square error of 57 min, with predictions accurate to within ± 1 h in 75% of participants and ± 2 h in 96%. We conclude that circadian phase prediction from light data is a viable technique for improving screening, diagnosis, and treatment of DSWPD.

Identifiants

DOI: 10.1038/s41598-021-89924-8 PMID: 34035333 PMC: PMC8149449
pubmed: 34035333
doi: 10.1038/s41598-021-89924-8
pii: 10.1038/s41598-021-89924-8
pmc: PMC8149449
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10878

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Auteurs

Jade M Murray (JM)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.

Michelle Magee (M)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.
Centre for Neuroscience of Speech, Department of Audiology and Speech Pathology, University of Melbourne, Melbourne, VIC, Australia.

Tracey L Sletten (TL)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.

Christopher Gordon (C)

Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.
Woolcock Institute of Medical Research and Sydney Local Health District, Sydney, NSW, Australia.
University of Sydney Susan Wakil School of Nursing, Camperdown, NSW, Australia.

Nicole Lovato (N)

Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Krutika Ambani (K)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.

Delwyn J Bartlett (DJ)

Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.
Woolcock Institute of Medical Research and Sydney Local Health District, Sydney, NSW, Australia.

David J Kennaway (DJ)

Robinson Research Institute and School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Leon C Lack (LC)

Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Ronald R Grunstein (RR)

Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.
Woolcock Institute of Medical Research and Sydney Local Health District, Sydney, NSW, Australia.

Steven W Lockley (SW)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

Shantha M W Rajaratnam (SMW)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia.
NHMRC Centre for Sleep and Circadian Neurobiology, Sydney, NSW, Australia.
Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

Andrew J K Phillips (AJK)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. andrew.phillips@monash.edu.
Cooperative Research Centre for Alertness, Safety and Productivity, Clayton, VIC, Australia. andrew.phillips@monash.edu.

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questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Light-based methods for predicting circadian...
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