Dynamic alterations in the central glutamatergic status following food and glucose intake:
Adult
Animals
Blood Glucose
/ analysis
Brain
/ diagnostic imaging
Central Nervous System
/ physiology
Eating
/ physiology
Glucose
/ administration & dosage
Glutamic Acid
/ metabolism
Humans
Kinetics
Magnetic Resonance Spectroscopy
/ methods
Male
Models, Animal
Multimodal Imaging
/ methods
Positron-Emission Tomography
/ methods
Rats
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5
/ metabolism
Synaptic Transmission
/ physiology
glucose
glutamate
magnetic resonance spectroscopy
metabotropic glutamate receptor subtype 5
positron emission tomography
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
pubmed:
28
5
2021
medline:
18
12
2021
entrez:
27
5
2021
Statut:
ppublish
Résumé
Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remains elusive. Here, we provide the first demonstration by bimodal positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) that metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in human brains are dynamically altered in a manner dependent on food intake and consequent changes in plasma glucose levels. The brain-wide modulations of central mGluR5 ligand binding and glutamate levels and profound neuronal activations following systemic glucose administration were further proven by PET, MRS, and intravital two-photon microscopy, respectively, in living rodents. The present findings consistently support the notion that food-associated glucose intake is mechanistically linked to glutamatergic tones in the brain, which are translationally accessible
Identifiants
pubmed: 34039039
doi: 10.1177/0271678X211004150
pmc: PMC8545038
doi:
Substances chimiques
Blood Glucose
0
Receptor, Metabotropic Glutamate 5
0
Glutamic Acid
3KX376GY7L
Glucose
IY9XDZ35W2
Types de publication
Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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