Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses.

Aged Apolipoprotein E2 / genetics Apolipoprotein E4 / genetics Attention Cognition Cognitive Dysfunction / diagnosis Cohort Studies Executive Function Female Genetic Association Studies Genetic Variation / genetics Heterozygote Humans Male Memory, Short-Term Middle Aged Neurodegenerative Diseases / complications Neuropsychological Tests
APOE Cognitive impairment E2 E4 Neurodegenerative disease Neuropsychology

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
09 2021
Historique:
received: 22 12 2020
revised: 16 03 2021
accepted: 14 04 2021
pubmed: 28 5 2021
medline: 24 12 2021
entrez: 27 5 2021
Statut: ppublish

Résumé

For many years there has been uncertainty regarding how apolipoprotein E (APOE) E2 and E4 variants may influence overlapping features of neurodegeneration, such as cognitive impairment. We aimed to identify whether the APOE variants are associated with cognitive function across various neurodegenerative and cerebrovascular diagnoses (n = 513). Utilizing a comprehensive neuropsychology battery, multivariate multiple regression was used to assess the influence of APOE carrier status and disease cohort on performance across five cognitive domains. Irrespective of disease cohort, E4 carriers had significantly lower performance in verbal memory and visuospatial domains than those with E3/3, while E2 carriers' cognitive performance was not significantly different. However, E2 carriers with frontotemporal dementia (FTD) performed significantly worse than those with E3/3 in the attention/working memory, executive function, and visuospatial domains. Our results highlight that the influence of APOE variation on cognition is complex, in some cases varying based on diagnosis and possibly underlying disease pathology.

Identifiants

DOI: 10.1016/j.neurobiolaging.2021.04.011 PMID: 34039480
pubmed: 34039480
pii: S0197-4580(21)00126-3
doi: 10.1016/j.neurobiolaging.2021.04.011
pii:
doi:

Substances chimiques

Apolipoprotein E2 0
Apolipoprotein E4 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

378.e1-378.e9

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Allison A Dilliott (AA)

Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address: adilliot@uwo.ca.

Kelly M Sunderland (KM)

Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.

Paula M McLaughlin (PM)

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada; Nova Scotia Health Authority & Dalhousie University, Halifax, Nova Scotia, Canada.

Angela C Roberts (AC)

Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA; School of Communication Sciences and Disorders, Elborn College, Western University, London, Ontario, Canada.

Emily C Evans (EC)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada.

Agessandro Abrahao (A)

Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.

Malcolm A Binns (MA)

Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Sandra E Black (SE)

Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; LCCampbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program Sunnybrook Health Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Michael Borrie (M)

St. Joseph's Health Care Centre, London, Ontario, Canada; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Leanne K Casaubon (LK)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; University Health Network Stroke Program, Toronto Western Hospital, Toronto, Ontario, Canada.

Dar Dowlatshahi (D)

Nova Scotia Health Authority & Dalhousie University, Halifax, Nova Scotia, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Elizabeth Finger (E)

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.

Corinne E Fischer (CE)

Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Andrew Frank (A)

Nova Scotia Health Authority & Dalhousie University, Halifax, Nova Scotia, Canada; Bruyère Research Institute, Ottawa, Ontario, Canada.

Morris Freedman (M)

Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; Division of Neurology, Baycrest Health Sciences, Toronto, Ontario, Canada.

David Grimes (D)

Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Ayman Hassan (A)

Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada.

Mandar Jog (M)

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; London Health Sciences Centre, London, Ontario, Canada.

Sanjeev Kumar (S)

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Donna Kwan (D)

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.

Anthony E Lang (AE)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

Jennifer Mandzia (J)

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Connie Marras (C)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

Mario Masellis (M)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Cognitive & Movement Disorders Clinic and L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Science Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Adam D McIntyre (AD)

Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Stephen Pasternak (S)

Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Cognitive Neurology and Alzheimer's Disease Research Centre, Parkwood Institute, St. Joseph's Health Care, London, Ontario, Canada.

Bruce G Pollock (BG)

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Tarek K Rajji (TK)

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.

John F Robinson (JF)

Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Ekaterina Rogaeva (E)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Demetrios J Sahlas (DJ)

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Gustavo Saposnik (G)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Clinical Outcomes and Decision Neuroscience Unit, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Christine Sato (C)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Dallas Seitz (D)

Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Christen Shoesmith (C)

London Health Sciences Centre, London, Ontario, Canada.

Thomas Steeves (T)

Division of Neurology, St. Michael's Hospital, Toronto, Ontario, Canada.

Stephen C Strother (SC)

Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Richard H Swartz (RH)

Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada; LCCampbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program Sunnybrook Health Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Brian Tan (B)

Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.

David Tang-Wai (D)

Department of Medicine, University of Toronto, Mississauga, Ontario, Canada; Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada; University Health Network Memory Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

Maria C Tartaglia (MC)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Angela K Troyer (AK)

Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Neuropsychology and Cognitive Health Program, Baycrest Health Sciences, Toronto, Ontario, Canada.

John Turnbull (J)

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Lorne Zinman (L)

Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.

Robert A Hegele (RA)

Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of apolipoprotein E variation with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E2 › Association of apolipoprotein E variation with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Association of apolipoprotein E variation with...
questionsmedicales.fr › Phénomènes psychologiques › Attention › Association of apolipoprotein E variation with...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Association of apolipoprotein E variation with...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Association of apolipoprotein E variation with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Association of apolipoprotein E variation with...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Fonction exécutive › Association of apolipoprotein E variation with...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Association of apolipoprotein E variation with...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Association of apolipoprotein E variation with...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Association of apolipoprotein E variation with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of apolipoprotein E variation with...
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questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Association of apolipoprotein E variation with...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Association of apolipoprotein E variation with...