Physiological and pharmacological impact of oxytocin on epididymal propulsion during the ejaculatory process in rodents and men.
contraction
epididymis
human
noradrenaline
oxytocin
sperm transport
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
09
04
2021
received:
11
03
2021
accepted:
15
04
2021
entrez:
27
5
2021
pubmed:
28
5
2021
medline:
20
7
2021
Statut:
ppublish
Résumé
During the emission phase of ejaculation, the sperm is driven from the cauda epididymidis, where it is stored, through the vas deferens by strong contractions. These contractions are thought of as being mainly induced by the sympathetic nervous system and the neurotransmitter noradrenaline. In the present study, we investigated the effect of oxytocin (suggested to exert effects during ejaculation as well) on defined segments of the rat and human epididymis using live imaging. Our results indicate that it is the very last part of the epididymis, segment 19 (S19) in rat and likewise segment 9 in human, which responds in a uniquely strong and rapid manner to oxytocin (similar to noradrenaline). Because of the complex nature of this contractile response, we developed an imaging analysis method, which allowed us to quantify multidirectional contractions and to display them using heat maps. The reaction of S19 to oxytocin was concentration-dependent and could be inhibited by pretreatment with oxytocin antagonists (atosiban and cligosiban), but not with an arginine vasopressin 1
Identifiants
pubmed: 34041782
doi: 10.1096/fj.202100435R
doi:
Substances chimiques
Antidiuretic Hormone Receptor Antagonists
0
Receptors, Oxytocin
0
Receptors, Vasopressin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21639Informations de copyright
© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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