Design, synthesis, and insecticidal activities of propargyloxy-naphthalene-sulfonamide derivatives.

Drug Design Insecticides / pharmacology Molecular Docking Simulation Molecular Structure Naphthalenes / pharmacology Structure-Activity Relationship Sulfonamides / pharmacology
Naphthalenesulfonamide insecticidal activity molecular docking structure–activity relationship

Journal

Journal of Asian natural products research
ISSN: 1477-2213
Titre abrégé: J Asian Nat Prod Res
Pays: England
ID NLM: 100888334

Informations de publication

Date de publication:
Apr 2022
Historique:
pubmed: 28 5 2021
medline: 24 3 2022
entrez: 27 5 2021
Statut: ppublish

Résumé

In our previous studies, a kind of novel benzenesulfonamides was found to be a candidate insecticidal compounds. It was shown that propargyloxy and sulfonamide groups are pharmacodynamic groups. One hundred and twenty-six (126) naphthalenesulfonamides derivatives with propargyloxy functionality were designed and synthesized, and their insecticidal activities were determined. Some of them showed outstanding activity, with LC

Identifiants

DOI: 10.1080/10286020.2021.1925254 PMID: 34042537
pubmed: 34042537
doi: 10.1080/10286020.2021.1925254
doi:

Substances chimiques

Insecticides 0
Naphthalenes 0
Sulfonamides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

361-370

Auteurs

Wang-Yu Zhao (WY)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Chao-Fu Yang (CF)

Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.
Department of Pharmacy, Changzhi Medical College, Changzhi 046000, China.

Li-Juan Han (LJ)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Bo Zhou (B)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Ai-Juan Li (AJ)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Lu-Lu Liu (LL)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Zi-Wei Zhang (ZW)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Zi-Yu Wang (ZY)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Wen-Jun Wu (WJ)

Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.

Ji-Wen Zhang (JW)

College of Chemistry & Pharmacy, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, China.
Key Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling 712100, China.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design, synthesis, and insecticidal activities...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Insecticides › Design, synthesis, and insecticidal activities...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Design, synthesis, and insecticidal activities...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Design, synthesis, and insecticidal activities...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Design, synthesis, and insecticidal activities...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, synthesis, and insecticidal activities...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Design, synthesis, and insecticidal activities...