Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study.
Covid-19
Hyperthyroidism
SARS-CoV2
Thyroid
Thyroiditis
Thyrotoxicosis
Journal
Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
01
03
2021
accepted:
06
05
2021
pubmed:
29
5
2021
medline:
14
7
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
To evaluate the post- coronavirus disease-19 (COVID-19) outcome of thyroid function in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyrotoxicosis. This was a single-center prospective study involving 29 patients (11 females, 18 males; median age 64 years, range: 43-85) with thyrotoxicosis diagnosed after hospitalization for COVID-19 and then followed-up for a median period of 90 days (range: 30-120) after hospital discharge. At follow-up, patients were evaluated for serum thyrotropin (TSH), free-thyroxine (FT4), free-triiodiothyronine (FT3), TSH receptor antibodies (TRAb), thyroglobulin antibodies (TgAb), thyroperoxidase antibodies (TPOAb) and ultrasonographic thyroid structure. After recovery of COVID-19, serum TSH values significantly increased (P < 0.001) and FT4 values significantly decreased (P = 0.001), without significant change in serum FT3 (P = 0.572). At follow-up, 28 subjects (96.6%) became euthyroid whereas overt hypothyroidism developed in one case. At the ultrasound evaluation of thyroid gland, hypoecogenicity was found in 10 patients (34.5%) and in these cases serum TSH values tended to be higher than those without thyroid hypoecogenity (P = 0.066). All subjects resulted to be negative for TgAb, TPOAb and TRAb. In a short-term follow-up, thyroid function spontaneously normalized in most subjects with SARS-CoV-2-related thyrotoxicosis. However, thyroid hypoecogenicity was found in a remarkable number of them and future longer-term studies are needed to clarify whether this ultrasonographic alteration may predispose to develop late-onset thyroid dysfunction.
Identifiants
pubmed: 34047879
doi: 10.1007/s12020-021-02758-2
pii: 10.1007/s12020-021-02758-2
pmc: PMC8161706
doi:
Substances chimiques
Autoantibodies
0
Thyrotropin
9002-71-5
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
255-260Investigateurs
Stefano Accornero
(S)
Alessio Aghemo
(A)
Ludovico Alfarone
(L)
Hussam Ali
(H)
Monia Aloise
(M)
Claudio Angelini
(C)
Ivan Arcari
(I)
Paola Arosio
(P)
Elena Azzolini
(E)
Alessandra Baccarin
(A)
Salvatore Badalamenti
(S)
Sara Baggio
(S)
Luca Balzarini
(L)
Caterina Barberi
(C)
Franca Barbic
(F)
Viviana Barbieri
(V)
Alessandro Barbone
(A)
Alessio Basciu
(A)
Chiara Benvenuti
(C)
Ilaria Bianchi
(I)
Monica Bocciolone
(M)
Cristiana Bonifacio
(C)
Federica Borea
(F)
Mario Borroni
(M)
Gianluigi Bresciani
(G)
Enrico Brunetta
(E)
Cinzia Bulletti
(C)
Cristina Cadonati
(C)
Lorenzo Calabro'
(L)
Marta Calatroni
(M)
Giuseppe Caltagirone
(G)
Albania Antonietta Calvetta
(AA)
Francesco Cannata
(F)
Lorenzo Canziani
(L)
Antonio Capogreco
(A)
Giovanni Luigi Capretti
(GL)
Elisa Carlani
(E)
Flaminia Carrone
(F)
Maddalena Casana
(M)
Alice Castelli
(A)
Elena Castelnuovo
(E)
Angela Ceribelli
(A)
Carlo Ceriotti
(C)
Manuel Chiarito
(M)
Michele Ciccarelli
(M)
Matteo Cimino
(M)
Gianluigi Citterio
(G)
Leonardo Ciuffini
(L)
Chiara Colaizzi
(C)
Francesca Colapietro
(F)
Guido Costa
(G)
Ottavia Cozzi
(O)
Vincenzo Craviotto
(V)
Chiara Crespi
(C)
Massimo Crippa
(M)
Federica D'Antonio
(F)
Felice D'Antuono
(F)
Federico D'Orazio
(F)
Sara Dal Farra
(SD)
Leonardo Da Rio
(L)
Guido De Ambroggi
(G)
Massimo De Donato
(M)
Francesca De Lucia
(F)
Pasquale De Nittis
(P)
Giacomo Delle Rose
(GD)
Antonio Desai
(A)
Maria De Santis
(M)
Marina Di Pilla
(M)
Franca Dipaola
(F)
Andrea Dipasquale
(A)
Angelo Dipasquale
(A)
Ginevra Droandi
(G)
Roberta Fazio
(R)
Giuseppe Favacchio
(G)
Carlo Fedeli
(C)
Giuseppe Ferrante
(G)
Elisa Chiara Ferrara
(EC)
Matteo Carlo Ferrari
(MC)
Sebastian Ferri
(S)
Marco Folci
(M)
Sara Foresti
(S)
Eloisa Franchi
(E)
Elia Fraolini
(E)
Federica Furfaro
(F)
Paola Galimberti
(P)
Alessia Galtieri
(A)
Maria Gardini
(M)
Francesca Gavazzi
(F)
Elena Generali
(E)
Caterina Giannitto
(C)
Massimo Giovanni Giorgino
(MG)
Benedetta Goletti
(B)
Elisabetta Guarino
(E)
Jacopo Guerrini
(J)
Giacomo Guidelli
(G)
Flavia Jacobs
(F)
Hayato Kurihara
(H)
Michele Lagioia
(M)
Andrea Lania
(A)
Ezio Lanza
(E)
Elisabetta Lavezzi
(E)
Luca Libre'
(L)
Ana Lleo
(A)
Ferdinando Loiacono
(F)
Laura Loy
(L)
Giovanni Lughezzani
(G)
Fabio Lutman
(F)
Marta Maccallini
(M)
Paola Magnoni
(P)
Alfonso Francesco Maiorino
(AF)
Alberto Malesci
(A)
Riccardo Mantovani
(R)
Davide Marchettini
(D)
Arianna Marinello
(A)
Nikolaos Markopoulos
(N)
Enrico Marrano
(E)
Chiara Masetti
(C)
Gherardo Mazziotti
(G)
Angelo Milani
(A)
Marco Mirani
(M)
Paola Morelli
(P)
Francesca Motta
(F)
Federica Mrakic Sposta
(FM)
Valeria Mundula
(V)
Irene Nasone
(I)
Mattia Nigro
(M)
Paolo Omodei
(P)
Monica Ormas
(M)
Arianna Pagliaro
(A)
Silvia Paiardi
(S)
Roberta Paliotti
(R)
Alessia Pavesi
(A)
Rosa Pedale
(R)
Vittorio Pedicini
(V)
Francesco Pegoraro
(F)
Gaia Pellegatta
(G)
Marta Pellegrino
(M)
Alessandra Pestalozza
(A)
Gennaro Petriello
(G)
Sara Piccini
(S)
Giorgio Pivato
(G)
Daria Pocaterra
(D)
Laura Poliani
(L)
Dario Poretti
(D)
Paoletta Preatoni
(P)
Fabio Procopio
(F)
Manuel Profili
(M)
Francesca Puggioni
(F)
Luca Pugliese
(L)
Nicola Pugliese
(N)
Francesca Racca
(F)
Michele Randazzo
(M)
Damiano Regazzoli Lancini
(DR)
Francesco Reggiani
(F)
Marta Ripoll Pons
(MR)
Stefano Rodolfi
(S)
Giulia Ronzoni
(G)
Lidia Ruongo
(L)
Clara Sacco
(C)
Michele Sagasta
(M)
Maria Teresa Sandri
(MT)
Giuseppe Sarra
(G)
Marzia Savi
(M)
Iside Scarfo'
(I)
Dana Shiffer
(D)
Federico Sicoli
(F)
Simone Solano
(S)
Virginia Solitano
(V)
Anna Stainer
(A)
Matteo Carlo Stella
(MC)
Giuseppe Strangio
(G)
Antonio Taormina
(A)
Francesca Ilaria Teofilo
(FI)
Lucia Testoni
(L)
Federica Tordato
(F)
Chiara Torrisi
(C)
Angela Trabucco
(A)
Luisa Ulian
(L)
Rossella Valentino
(R)
Chiara Valeriano
(C)
Walter Vena
(W)
Simona Verlingieri
(S)
Edoardo Vespa
(E)
Antonio Voza
(A)
Giuseppe Voza
(G)
Valentina Zanuso
(V)
Alessandra Zilli
(A)
Aurora Zumbo
(A)
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