Sleep, Orexin and Cognition.

Aging / metabolism Alzheimer Disease / drug therapy Animals Anorexia Nervosa / metabolism Cognitive Dysfunction / drug therapy Humans Narcolepsy / complications Orexin Receptors / drug effects Orexins / metabolism Parkinson Disease / drug therapy Sleep / physiology

Journal

Frontiers of neurology and neuroscience
ISSN: 1662-2804
Titre abrégé: Front Neurol Neurosci
Pays: Switzerland
ID NLM: 101274949

Informations de publication

Date de publication:
2021
Historique:
received: 30 07 2020
accepted: 02 02 2021
entrez: 30 5 2021
pubmed: 31 5 2021
medline: 30 11 2021
Statut: ppublish

Résumé

Orexins regulate a wide variety of biological functions, most notably the sleep-wake cycle, reward and stress processing, alertness, vigilance, and cognitive functioning. Alterations of central and peripheral orexin levels are linked to conditions such as narcolepsy, anorexia nervosa, age-related cognitive decline, and neurodegenerative disease. Preliminary studies suggest that orexin mimetics can safely promote the wake signal via orexin agonism during the day and that orexin receptor antagonists can promote the sleep signal during the night. Thus, novel orexin therapies have the potential to either improve memory, cognition, and daytime performance directly or indirectly, through promotion of good sleep. The full scope of the therapeutic potential of orexin therapies remains to be elucidated.

Identifiants

DOI: 10.1159/000514960 PMID: 34052810
pubmed: 34052810
pii: 000514960
doi: 10.1159/000514960
doi:

Substances chimiques

Orexin Receptors 0
Orexins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

38-51

Informations de copyright

© 2021 The Author(s). Published by S. Karger AG, Basel.

Auteurs

Balmeet Toor (B)

School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.

Laura B Ray (LB)

School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
Sleep Unit, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.

Alyssa Pozzobon (A)

School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.

Stuart M Fogel (SM)

School of Psychology, University of Ottawa, Ottawa, Ontario, Canada.
Sleep Unit, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Sleep, Orexin and Cognition.
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Sleep, Orexin and Cognition.
questionsmedicales.fr › Eucaryotes › Animaux › Sleep, Orexin and Cognition.
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Anorexie mentale › Sleep, Orexin and Cognition.
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Sleep, Orexin and Cognition.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sleep, Orexin and Cognition.
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles du sommeil par somnolence excessive › Narcolepsie › Sleep, Orexin and Cognition.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs des orexines › Sleep, Orexin and Cognition.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Orexines › Sleep, Orexin and Cognition.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Sleep, Orexin and Cognition.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Sleep, Orexin and Cognition.