The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin System.
Journal
Frontiers of neurology and neuroscience
ISSN: 1662-2804
Titre abrégé: Front Neurol Neurosci
Pays: Switzerland
ID NLM: 101274949
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
08
2020
accepted:
02
02
2021
entrez:
30
5
2021
pubmed:
31
5
2021
medline:
30
11
2021
Statut:
ppublish
Résumé
Significant sleep impairments often accompany substance use disorders (SUDs). Sleep disturbances in SUD patients are associated with poor clinical outcomes and treatment adherence, emphasizing the importance of normalizing sleep when treating SUDs. Orexins (hypocretins) are neuropeptides exclusively produced by neurons in the posterior hypothalamus that regulate various behavioral and physiological processes, including sleep-wakefulness and motivated drug taking. Given its dual role in sleep and addiction, the orexin system represents a promising therapeutic target for treating SUDs and their comorbid sleep deficits. Here, we review the literature on the role of the orexin system in sleep and drug addiction and discuss the therapeutic potential of orexin receptor antagonists for SUDs. We argue that orexin receptor antagonists may be effective therapeutics for treating addiction because they target orexin's regulation of sleep (top-down) and motivation (bottom-up) pathways.
Identifiants
pubmed: 34052815
pii: 000514965
doi: 10.1159/000514965
pmc: PMC8324012
mid: NIHMS1725251
doi:
Substances chimiques
Orexin Receptor Antagonists
0
Orexins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-127Subventions
Organisme : NIGMS NIH HHS
ID : K12 GM093854
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA045765
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA045765
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA006214
Pays : United States
Informations de copyright
© 2021 The Author(s). Published by S. Karger AG, Basel.
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