Olaparib attenuates sepsis-induced acute multiple organ injury via ERK-mediated CD14 expression.
Animals
Anti-Inflammatory Agents
/ therapeutic use
Cytokines
/ metabolism
Disease Models, Animal
Inflammation
/ drug therapy
Inflammation Mediators
/ metabolism
Lipopolysaccharide Receptors
/ drug effects
Lung
/ metabolism
Male
Mice
Phthalazines
/ pharmacology
Piperazines
/ pharmacology
Sepsis
/ drug therapy
CD14
ERK
Olaparib
lung injury
sepsis
Journal
Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
1
6
2021
medline:
1
12
2021
entrez:
31
5
2021
Statut:
ppublish
Résumé
Sepsis is characterized by persistent systemic inflammation, which can cause multi-organ dysfunction. The poly polymerase-1 inhibitor olaparib possesses anti-inflammatory properties. This study aimed to assess the effects of olaparib (pre- and post-treatments) on sepsis, and to investigate whether it could suppress CD14 expression via the ERK pathway in polymicrobial sepsis and peritoneal macrophages models. Sepsis was induced by cecal ligation and puncture in C57BL/6 male mice. Fifty mice were randomly divided into five groups: The sham group was treated with vehicle or olaparib, the cecal ligation and puncture group with vehicle or with olaparib (5 mg/kg i.p.) 1 h before or 2 h after surgery. Olaparib pretreatment significantly improved the survival of septic mice (
Identifiants
pubmed: 34053236
doi: 10.1177/15353702211015620
pmc: PMC8424638
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cd14 protein, mouse
0
Cytokines
0
Inflammation Mediators
0
Lipopolysaccharide Receptors
0
Phthalazines
0
Piperazines
0
olaparib
WOH1JD9AR8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1948-1958Références
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