Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes Than the Healthy Housemates.
CVID
Hungatella hathewayi
common variable immunodeficiency
metabolome
metagenome
microbiome
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
02
2021
accepted:
26
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous disorder with inadequate antibody responses and low levels of immunoglobulins including IgA that is involved in the maintenance of the intestinal homeostasis. In this study, we analyzed the taxonomical and functional metagenome of the fecal microbiota and stool metabolome in a cohort of six CVID patients without gastroenterological symptomatology and their healthy housemates. The fecal microbiome of CVID patients contained higher numbers of bacterial species and altered abundance of thirty-four species.
Identifiants
pubmed: 34054845
doi: 10.3389/fimmu.2021.671239
pmc: PMC8163231
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
671239Informations de copyright
Copyright © 2021 Bosák, Lexa, Fiedorová, Gadara, Micenková, Spacil, Litzman, Freiberger and Šmajs.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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