The "Intermediate" CD14 + CD16 + monocyte subpopulation plays a role in IVIG responsiveness of children with Kawasaki disease.
Biomarkers, Pharmacological
/ analysis
Child, Preschool
Female
Fever
/ blood
Flow Cytometry
/ methods
GPI-Linked Proteins
/ immunology
Humans
Immunoglobulins, Intravenous
/ administration & dosage
Immunologic Factors
/ administration & dosage
Immunophenotyping
/ methods
Lipopolysaccharide Receptors
/ immunology
Male
Monocytes
/ immunology
Mucocutaneous Lymph Node Syndrome
/ blood
Patient Acuity
Receptors, IgG
/ immunology
Treatment Outcome
IVIG responsiveness
IVIG-resistant
Immunity
Intermediate monocyte
Kawasaki disease
Journal
Pediatric rheumatology online journal
ISSN: 1546-0096
Titre abrégé: Pediatr Rheumatol Online J
Pays: England
ID NLM: 101248897
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
19
12
2020
accepted:
20
05
2021
entrez:
1
6
2021
pubmed:
2
6
2021
medline:
27
11
2021
Statut:
epublish
Résumé
Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause. Intravenous immunoglobulin (IVIG)-resistance are related to greater risk for permanent cardiac complications. We aimed to determine the correlation between monocytes and the phenotype of KD in relation to IVIG responsiveness in children. The study cohort included 62 patients who were diagnosed with KD, 20 non febrile healthy controls (NFC), and 15 other febrile controls (OFC). In all enrolled patients, blood was taken at least 4 times and laboratory tests were performed. In addition, subtypes of monocytes were characterized via flow cytometry. The numbers of intermediate monocytes were significantly lower in IVIG-resistant group compared to IVIG-responsive group before IVIG infusion (p < 0.0001). After infusion, intermediate monocytes decreased in the responsive group, while a trend of increase was observed in the resistant group. Only intermediate monocytes were significant in logistic regression with adjusted OR of 0.001 and p value of 0.03. CD14 + CD16 + intermediate monocyte may play an important role in IVIG responsiveness among KD children. Low starting levels of intermediate monocytes, followed by a dramatic increase post-IVIG infusion during acute phase of KD are associated with IVIG-resistance. Functional studies on intermediate monocyte may help to reveal the pathophysiology.
Sections du résumé
BACKGROUND
BACKGROUND
Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause. Intravenous immunoglobulin (IVIG)-resistance are related to greater risk for permanent cardiac complications. We aimed to determine the correlation between monocytes and the phenotype of KD in relation to IVIG responsiveness in children.
MATERIALS AND METHODS
METHODS
The study cohort included 62 patients who were diagnosed with KD, 20 non febrile healthy controls (NFC), and 15 other febrile controls (OFC). In all enrolled patients, blood was taken at least 4 times and laboratory tests were performed. In addition, subtypes of monocytes were characterized via flow cytometry.
RESULTS
RESULTS
The numbers of intermediate monocytes were significantly lower in IVIG-resistant group compared to IVIG-responsive group before IVIG infusion (p < 0.0001). After infusion, intermediate monocytes decreased in the responsive group, while a trend of increase was observed in the resistant group. Only intermediate monocytes were significant in logistic regression with adjusted OR of 0.001 and p value of 0.03.
CONCLUSIONS
CONCLUSIONS
CD14 + CD16 + intermediate monocyte may play an important role in IVIG responsiveness among KD children. Low starting levels of intermediate monocytes, followed by a dramatic increase post-IVIG infusion during acute phase of KD are associated with IVIG-resistance. Functional studies on intermediate monocyte may help to reveal the pathophysiology.
Identifiants
pubmed: 34059085
doi: 10.1186/s12969-021-00573-7
pii: 10.1186/s12969-021-00573-7
pmc: PMC8165978
doi:
Substances chimiques
Biomarkers, Pharmacological
0
FCGR3B protein, human
0
GPI-Linked Proteins
0
Immunoglobulins, Intravenous
0
Immunologic Factors
0
Lipopolysaccharide Receptors
0
Receptors, IgG
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
76Subventions
Organisme : Biomedical institute of Chonnam National University Hospital
ID : BCR120006
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