The trans-ancestral genomic architecture of glycemic traits.
Alleles
Blood Glucose
/ genetics
Epigenesis, Genetic
Gene Expression Profiling
Genome, Human
Genome-Wide Association Study
Glycated Hemoglobin
/ metabolism
Humans
Multifactorial Inheritance
/ genetics
Physical Chromosome Mapping
Quantitative Trait Loci
/ genetics
Quantitative Trait, Heritable
White People
/ genetics
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
07
07
2020
accepted:
22
03
2021
pubmed:
2
6
2021
medline:
21
7
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10
Identifiants
pubmed: 34059833
doi: 10.1038/s41588-021-00852-9
pii: 10.1038/s41588-021-00852-9
pmc: PMC7610958
mid: EMS120610
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
840-860Subventions
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Investigateurs
Hugoline G de Haan
(HG)
Erik van den Akker
(E)
Peter J van der Most
(PJ)
Eco J C de Geus
(EJC)
Rob M van Dam
(RM)
Diana van Heemst
(D)
Astrid van Hylckama Vlieg
(A)
Ko van Willems van Dijk
(K)
H Janaka de Silva
(HJ)
Pim van der Harst
(P)
Cornelia van Duijn
(C)
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