The protective effect of α7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats.
5-HT1B/1D receptor
glutamate
inflammation
intestinal ischemia-reperfusion
rat
α7-nACh receptor
Journal
Fundamental & clinical pharmacology
ISSN: 1472-8206
Titre abrégé: Fundam Clin Pharmacol
Pays: England
ID NLM: 8710411
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
08
05
2021
received:
01
03
2021
accepted:
28
05
2021
pubmed:
2
6
2021
medline:
18
1
2022
entrez:
1
6
2021
Statut:
ppublish
Résumé
Over the past decades, great attention has been given to the nervous system modulating effects on the immune response in inflammation-associated injuries, such as acute intestinal ischemia-reperfusion (IR). Recently, we proved the anti-inflammatory and antioxidant effects of 5-hydroxytryptamine (5-HT)1B/1D receptors in intestinal IR injury in rats. Also, the alpha7 nicotinic acetylcholine (α7-nACh) receptor has anti-inflammatory effects in different inflammation-associated injuries. Starting from these premises, we aimed to examine the function of the α7-nACh receptors and the functional interactions between the anti-inflammatory and antioxidant effects of α7-nACh and 5-HT1B/1D receptors in acute intestinal IR injury. To confirm the expression and localization of α7-nACh receptors on the ileum nerves, an immunofluorescence-based method was applied. Then, intestinal IR injury was induced by 30-min occlusion of superior mesenteric artery and reperfusion for 2 h in rats. Acute systemic administration of α7-nACh receptor agonist PNU-282987 and antagonist methyllycaconitine, and 5-HT1B/1D receptors agonist (sumatriptan) and antagonist (GR127, 935) were used in the model of intestinal IR injury. Finally, biochemical and histological parameters were assessed. Α7-nACh receptors were expressed by 9% on the ileum nerves. Likewise, activation of the α7-nACh receptor showed anti-inflammatory and antioxidant effects in intestinal IR injury but not as well as 5-HT1B/1D receptors. Interestingly, 5-HT1B/1D receptors via attenuation of glutamate (Glu) release indirectly activated the α7-nACh receptor and its protective effects against inflammation and oxidative stress. The protective effect of the α7-nACh receptor on intestinal IR injury was activated indirectly through the 5-HT1B/1D receptors' modulatory impact on Glu release.
Substances chimiques
Chrna7 protein, rat
0
Receptor, Serotonin, 5-HT1B
0
Receptor, Serotonin, 5-HT1D
0
Serotonin 5-HT1 Receptor Agonists
0
alpha7 Nicotinic Acetylcholine Receptor
0
Sumatriptan
8R78F6L9VO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-113Subventions
Organisme : Research Council of Tehran University of Medical Sciences, Tehran, Iran.
ID : 97-01-30-37506
Organisme : Iran National Science Foundation (INSF)
ID : 96002757
Informations de copyright
© 2021 Société Française de Pharmacologie et de Thérapeutique.
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