Charged Residues Flanking the Transmembrane Domain of Two Related Toxin-Antitoxin System Toxins Affect Host Response.
Enterococcus faecalis
Fst/Ldr family toxin 4
small protein toxins 3
type I toxin–antitoxin system 2
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
received:
15
03
2021
revised:
29
04
2021
accepted:
30
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
1
7
2021
Statut:
epublish
Résumé
A majority of toxins produced by type I toxin-antitoxin (TA-1) systems are small membrane-localized proteins that were initially proposed to kill cells by forming non-specific pores in the cytoplasmic membrane. The examination of the effects of numerous TA-1 systems indicates that this is not the mechanism of action of many of these proteins.
Identifiants
pubmed: 34062876
pii: toxins13050329
doi: 10.3390/toxins13050329
pmc: PMC8147318
pii:
doi:
Substances chimiques
Bacterial Toxins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI140037
Pays : United States
Organisme : NIH HHS
ID : AI140037
Pays : United States
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