Lutein Has a Positive Impact on Brain Health in Healthy Older Adults: A Systematic Review of Randomized Controlled Trials and Cohort Studies.
Aged
Brain
/ diagnostic imaging
Cognition
/ drug effects
Cognitive Aging
/ physiology
Cross-Sectional Studies
Eating
/ psychology
Female
Fruit
/ chemistry
Healthy Volunteers
Humans
Lutein
/ pharmacology
Magnetic Resonance Imaging
Male
Randomized Controlled Trials as Topic
Task Performance and Analysis
Vegetables
/ chemistry
MRI
VBM
brain
carotenoid
lutein
systematic review
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
05
04
2021
revised:
07
05
2021
accepted:
18
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
22
7
2021
Statut:
epublish
Résumé
A previous systematic review revealed that lutein intake leads to improved cognitive function among older adults. However, the association between lutein intake and brain health remains unclear. We searched the Web of Science, PubMed, PsycInfo, and Cochrane Library for research papers. The criteria were (1) an intervention study using oral lutein intake or a cross-sectional study that examined lutein levels and the brain, (2) participants were older adults, and (3) brain activities or structures were measured using a brain imaging technique (magnetic resonance imaging (MRI) or electroencephalography (EEG)). Seven studies using MRI (brain activities during rest, cognitive tasks, and brain structure) and two studies using EEG were included. We mainly focused on MRI studies. Three intervention studies using MRI indicated that 10 mg lutein intake over 12 months had a positive impact on healthy older adults' brain activities during learning, resting-state connectivity, and gray matter volumes. Four cross-sectional studies using MRI suggested that lutein was positively associated with brain structure and neural efficiency during cognitive tasks. Although only nine studies that used similar datasets were reviewed, this systematic review indicates that lutein has beneficial effects on healthy older adults' brain health.
Identifiants
pubmed: 34063827
pii: nu13061746
doi: 10.3390/nu13061746
pmc: PMC8223987
pii:
doi:
Substances chimiques
Lutein
X72A60C9MT
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Lion Corporation
ID : Research grant
Organisme : JSPS KAKENHI a Grant-in-Aid for Scientific Research (B)
ID : 16KT0002
Organisme : JSPS KAKENHI a Grant-in-Aid for Scientific Research (B)
ID : 19H01760
Organisme : JSPS KAKENHI a Grant-in-Aid for Scientific Research on Innovative Areas
ID : 19H05003
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