The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review.
Aging
Animals
Bone and Bones
/ metabolism
Cartilage
Dental Enamel
/ embryology
Dental Pulp
/ metabolism
Dentin
/ physiology
Gene Expression Profiling
Human Growth Hormone
/ metabolism
Humans
Insulin-Like Growth Factor I
/ biosynthesis
Insulin-Like Growth Factor II
/ biosynthesis
Mesoderm
/ pathology
Orthodontics
Osseointegration
Periodontal Ligament
/ metabolism
Recombinant Proteins
/ therapeutic use
Regeneration
Tissue Engineering
Tooth
/ embryology
GH
IGF
IGFBP
age-related pathologies
alveolar bone
animal models
bone repair
dental ligament
dentin
dentin repair
enamel
mandible
oral tissue engineering
orthodontic treatment
osseointegration
periodontal regeneration
tooth
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 05 2021
12 05 2021
Historique:
received:
29
03
2021
revised:
02
05
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
26
10
2021
Statut:
epublish
Résumé
The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.
Identifiants
pubmed: 34066078
pii: cells10051181
doi: 10.3390/cells10051181
pmc: PMC8150312
pii:
doi:
Substances chimiques
Recombinant Proteins
0
Human Growth Hormone
12629-01-5
Insulin-Like Growth Factor I
67763-96-6
Insulin-Like Growth Factor II
67763-97-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale Recherche
ID : ANR-18-IDEX-0001
Organisme : ANSES
ID : 2019/1/230
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